{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T09:55:53Z","timestamp":1753869353030,"version":"3.41.2"},"reference-count":31,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2022,2,21]],"date-time":"2022-02-21T00:00:00Z","timestamp":1645401600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Biochem &amp; Molecular Tox"],"published-print":{"date-parts":[[2022,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Cardiac channelopathies are a heterogeneous group of inherited cardiac diseases that are associated with mutations in the genes that encode the expression of cardiac ion channels. In view of this, it can be mentioned that the main hereditary arrhythmias in children and adolescents, caused by dysfunction of the ion channels, are Brugada Syndrome (BrS) and Long QT Syndrome (LQTS). However, few studies address the physiological effects of these conditions on children and adolescents. Thus, the aim of this study is to describe the mutation phenotype related to voltage\u2010gated sodium channels in children and adolescents. A search was performed in the literature of PubMed, Scielo, and Google scholar. The search was limited to articles written in the last 5 years, so articles published between 2014 and 2019 were included. Among 2196 studies identified through a systematic literature review, 30 studies related to the theme were identified for a complete review and after applying exclusion criteria, 4 articles were included in the results of this study. As the most frequently observed channelopathy, BrS was also more identified in children and adolescents, characterized by episodes of syncope or sudden cardiac death. LQTS shows clinical manifestations with a mild phenotype and good prognosis, although it is necessary to monitor and correct serum electrolyte disturbances to prevent ventricular arrhythmias and, consequently, sudden death in patients with the pathology. The aim of this study is to find the general phenotypes related to genetic mutations of voltage\u2010gated sodium channels, in a population aged from 7\u2010 to 14\u2010year\u2010old.<\/jats:p>","DOI":"10.1002\/jbt.22993","type":"journal-article","created":{"date-parts":[[2022,2,21]],"date-time":"2022-02-21T09:10:09Z","timestamp":1645434609000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Phenotypes of mutations related to voltage\u2010dependent sodium channels on children and adolescents"],"prefix":"10.1002","volume":"36","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1887-1256","authenticated-orcid":false,"given":"Andressa Coelho","family":"Ferreira","sequence":"first","affiliation":[{"name":"Laboratory of Cardiovascular Adaptations to Exercise\u2014LACORE, Physical Education Department University Federal of Maranh\u00e3o S\u00e3o Lu\u00eds Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1181-6411","authenticated-orcid":false,"given":"Carlos Alberto Alves","family":"Dias\u2010Filho","sequence":"additional","affiliation":[{"name":"Laboratory of Cardiovascular Adaptations to Exercise\u2014LACORE, Physical Education Department University Federal of Maranh\u00e3o S\u00e3o Lu\u00eds Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6469-7562","authenticated-orcid":false,"given":"Nivaldo","family":"de Jesus Silva Soares Junior","sequence":"additional","affiliation":[{"name":"Laboratory of Cardiovascular Adaptations to Exercise\u2014LACORE, Physical Education Department University Federal of Maranh\u00e3o S\u00e3o Lu\u00eds Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0508-0308","authenticated-orcid":false,"given":"Carlos Jos\u00e9","family":"Dias","sequence":"additional","affiliation":[{"name":"Laboratory of Cardiovascular Adaptations to Exercise\u2014LACORE, Physical Education Department University Federal of Maranh\u00e3o S\u00e3o Lu\u00eds Brazil"},{"name":"Physical Education Department UFMA Sao Luis Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3082-1101","authenticated-orcid":false,"given":"Sally Cristina Moutinho","family":"Monteiro","sequence":"additional","affiliation":[{"name":"Laboratory of Cardiovascular Adaptations to Exercise\u2014LACORE, Physical Education Department University Federal of Maranh\u00e3o S\u00e3o Lu\u00eds Brazil"},{"name":"Pharmacy Department UFMA Sao Luis Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4220-439X","authenticated-orcid":false,"given":"Rafael Martins","family":"Andrade","sequence":"additional","affiliation":[{"name":"Laboratory of Cardiovascular Adaptations to Exercise\u2014LACORE, Physical Education Department University Federal of Maranh\u00e3o S\u00e3o Lu\u00eds Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1305-1697","authenticated-orcid":false,"given":"Cristiano Teixeira","family":"Mostarda","sequence":"additional","affiliation":[{"name":"Laboratory of Cardiovascular Adaptations to Exercise\u2014LACORE, Physical Education Department University Federal of Maranh\u00e3o S\u00e3o Lu\u00eds Brazil"},{"name":"Pharmacy Department UFMA Sao Luis Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2022,2,21]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.116.305017"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2014.07.036"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/ejhg.2015.198"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.repc.2017.11.007"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1097\/HCO.0b013e328352429d"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1038\/23034"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.24953\/turkjped.2018.05.016"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1093\/europace\/euy041"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1038\/gim.2015.35"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.joa.2015.12.009"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1510687"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2016.00121"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.20344\/amp.11923"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1536\/ihj.17-686"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.5935\/abc.20180120"},{"issue":"15","key":"e_1_2_7_17_1","first-page":"2163","volume":"110","author":"McNair W. 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