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However, the effect of BPA on male fertility and gonadal development in diabetic (DIA) patients is unknown. This study explores the role of BPA exposure on testicular toxicity in a DIA rat. The DIA condition in male Sprague\u2013Dawley (SD) rats (4 weeks aged) was induced with the administration of a single dose of streptozotocin (55\u2009mg\/kg ip, in cold citrate buffer pH 4.5). BPA was administered orally at the dose of 40\u2009mg\/kg\/day for 4 consecutive weeks. Various endpoints of the toxicity include biochemical estimations, histological evaluations, oxidative stress parameters, DNA damage assays (apoptosis and endonuclease III), expressions of 8\u2010hydroxy\u20102\u02b9\u2010deoxyguanosine (8\u2010OHdG), nuclear factor\u2010erythroid 2\u2010related factor 2 (Nrf\u20102), catalase, superoxide dismutase 1 (SOD\u20101), octamer\u2010binding transcription factor 4 (OCT4), and Sirtulin (silent mating type information regulation 2 homolog) 1 (SIRT 1). The results confirmed that BPA exacerbated the testicular toxicity by altering several biochemical parameters, increasing oxidative stress, cellular\/tissue injury, DNA damage, apoptosis, and 8\u2010OHdG expression, while decreasing the levels of Nrf\u20102, catalase, SOD\u20101, OCT4, and SIRT1 expressions in the testes of DIA rat. Linear regression analyses indicated a positive correlation between apoptosis and 8\u2010OHdG, OCT4, and DNA damage (nuclear diffusion factor and tail length). The present study confirmed that BPA exposure in DIA conditions exacerbated the testicular damages in SD rats. Therefore, the DIA condition might have increased male gonadal toxicity due to BPA exposure and\u00a0requires further attention to maintain their normal reproductive health.<\/jats:p>","DOI":"10.1002\/jbt.22996","type":"journal-article","created":{"date-parts":[[2022,2,21]],"date-time":"2022-02-21T08:39:27Z","timestamp":1645432767000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Studies on male gonadal toxicity of bisphenol A in diabetic rats: An example of exacerbation effect"],"prefix":"10.1002","volume":"36","author":[{"given":"Chittaranjan","family":"Sahu","sequence":"first","affiliation":[{"name":"Department of Pharmacology and Toxicology, Facility for Risk Assessment and Intervention Studies National Institute of Pharmaceutical Education and Research,\u00a0S.A.S Nagar Sahibzada Ajit Singh Nagar Punjab India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shivani","family":"Singla","sequence":"additional","affiliation":[{"name":"Department of Pharmacology and Toxicology, Facility for Risk Assessment and Intervention Studies National Institute of Pharmaceutical Education and Research,\u00a0S.A.S Nagar Sahibzada Ajit Singh Nagar Punjab India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9437-7252","authenticated-orcid":false,"given":"Gopabandhu","family":"Jena","sequence":"additional","affiliation":[{"name":"Department of Pharmacology and Toxicology, Facility for Risk Assessment and Intervention Studies National Institute of Pharmaceutical Education and Research,\u00a0S.A.S Nagar Sahibzada Ajit Singh Nagar Punjab India"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2022,2,21]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.toxrep.2017.12.013"},{"key":"e_1_2_10_3_1","first-page":"5","volume":"66","author":"Konieczna A.","year":"2015","journal-title":"Rocz. 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