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This study was designed to evaluate the exposure of dry\u00a0 cleaning workers to perchloroethylene (PEC), and its liver and kidney damage, and oxidative stress in B\u2010lymphocytes isolated from the workers. Blood samples were evaluated for liver (alanine transaminase [ALT] and aspartate transaminase [AST]) and kidney (BUN and creatinine) markers. For measurement of PEC, exhaled, personal, and ambient air samples were collected and analyzed gas chromatography (GC\u2010FID) through the NIOSH 1003 and 3704 methods. Also, the parameters of oxidative stress including the level of reactive oxygen species (ROS), glutathione (GSH), oxidized glutathione (GSSG), and lipid peroxidation (LPO) in B\u2010lymphocytes were evaluated. The results showed that the levels of liver enzymes ALT and AST in dry cleaning workers are higher than in the control group. The personal exposure levels and exhaled air concentration of PEC in dry cleaning workers were above the recommended national occupational exposure limits (OELs) and the biological exposure index (BEI). The levels of ROS, LPO, and GSSG in B\u2010lymphocytes from the dry cleaning workers are higher than the control group, and the levels of GSH in dry cleaning workers are lower. The results suggested that exposure of dry cleaning workers to PEC could be associated with liver damage and oxidative damage in B\u2010lymphocytes.<\/jats:p>","DOI":"10.1002\/jbt.23000","type":"journal-article","created":{"date-parts":[[2022,2,14]],"date-time":"2022-02-14T07:55:15Z","timestamp":1644825315000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["The perchloroethylene\u2010induced toxicity in dry cleaning workers lymphocytes through induction of oxidative stress"],"prefix":"10.1002","volume":"36","author":[{"given":"Asghar","family":"Ghahri","sequence":"first","affiliation":[{"name":"Department of Occupational Health and Safety Engineering, School of Health Alborz University of Medical Sciences Karaj Iran"},{"name":"Research Center for Health, Safety and Environment Alborz University of Medical Sciences Karaj Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mohammad Hossien","family":"Dehghan","sequence":"additional","affiliation":[{"name":"Department of Biochemistry, Genetics, Nutrition and Immunology, School of Medicine Alborz University of Medical Sciences Karaj Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pouria","family":"Seydi","sequence":"additional","affiliation":[{"name":"Emergency Nursing Mazandaran University of Medical Sciences Sari Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sara","family":"Mashayekhi","sequence":"additional","affiliation":[{"name":"Department of Occupational Health and Safety Engineering, School of Health Alborz University of Medical Sciences Karaj Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yasaman","family":"Naderi","sequence":"additional","affiliation":[{"name":"Department of Occupational Health and Safety Engineering, School of Health Alborz University of Medical Sciences Karaj Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8524-946X","authenticated-orcid":false,"given":"Enayatollah","family":"Seydi","sequence":"additional","affiliation":[{"name":"Department of Occupational Health and Safety Engineering, School of Health Alborz University of Medical Sciences Karaj Iran"},{"name":"Research Center for Health, Safety and Environment Alborz University of Medical Sciences Karaj Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2022,2,13]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.15171\/ijoem.2017.1089"},{"key":"e_1_2_8_3_1","first-page":"727","volume-title":"Hamilton & Hardy's Industrial Toxicology","author":"Dodge D. 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