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Male Wistar rats were administered 1.5\u2009mg\/kg rotenone for 10\u2009days and subsequently treated with 0.25\u20131.0\u2009mg\/kg DHQ for 3\u2009days followed by the assessment of parkinsonian symptoms. Brain striatal redox stress and neurochemical dysfunction markers were assessed spectrophotometrically. Histopathological evaluation of the striatum was done by hematoxylin and eosin staining technique. The expression of genes involved in the activation of NF\u2010\u03baB signaling pathway (IL\u20101\u03b2, TNF\u2010\u03b1, NF\u2010\u03baB and I\u03baKB), and the p53 gene in the striatum were determined by RT\u2010qPCR. DHQ attenuated parkinsonian symptoms as well as striatal redox stress, neurochemical dysfunction, and histological alterations occasioned by rotenone toxicity. Importantly, DHQ significantly suppressed the rotenone\u2010induced upregulation of IL\u20101\u03b2, NF\u2010\u03baB, and I\u03baKB expression (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.05) in the striatum of parkinsonian rats. DHQ demonstrated notable neurotherapeutic potential against rotenone\u2010induced Parkinsonism in rats by improving parkinsonian symptoms (bradykinesia, catalepsy, postural instability, impaired locomotor behavior, and tremor) and neurochemical dysfunctions via modulation of genes involved in the activation of the canonical pathway of NF\u2010\u03baB\u2010mediated inflammation.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jbt.23022","type":"journal-article","created":{"date-parts":[[2022,2,21]],"date-time":"2022-02-21T08:53:25Z","timestamp":1645433605000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":31,"title":["Dihydroquercetin improves rotenone\u2010induced Parkinsonism by regulating NF\u2010\u03baB\u2010mediated inflammation pathway in rats"],"prefix":"10.1002","volume":"36","author":[{"given":"Afolabi C.","family":"Akinmoladun","sequence":"first","affiliation":[{"name":"Department of Biochemistry, School of Life Sciences The Federal University of Technology Akure Nigeria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Courage D.","family":"Famusiwa","sequence":"additional","affiliation":[{"name":"Department of Biochemistry, School of Life Sciences The Federal University of Technology Akure Nigeria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sunday S.","family":"Josiah","sequence":"additional","affiliation":[{"name":"Department of Biochemistry, School of Life Sciences The Federal University of Technology Akure Nigeria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akeem O.","family":"Lawal","sequence":"additional","affiliation":[{"name":"Department of Biochemistry, School of Life Sciences The Federal University of Technology Akure Nigeria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mary T.","family":"Olaleye","sequence":"additional","affiliation":[{"name":"Department of Biochemistry, School of Life Sciences The Federal University of Technology Akure Nigeria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Afolabi A.","family":"Akindahunsi","sequence":"additional","affiliation":[{"name":"Department of Biochemistry, School of Life Sciences The Federal University of Technology Akure Nigeria"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,2,21]]},"reference":[{"key":"e_1_2_9_2_1","unstructured":"A.Kouli K. 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