{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T14:47:58Z","timestamp":1786978078639,"version":"build-2736575974"},"reference-count":44,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2022,3,20]],"date-time":"2022-03-20T00:00:00Z","timestamp":1647734400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100004607","name":"Natural Science Foundation of Guangxi Province","doi-asserted-by":"publisher","award":["2018GXNSFAA050092"],"award-info":[{"award-number":["2018GXNSFAA050092"]}],"id":[{"id":"10.13039\/501100004607","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81960400"],"award-info":[{"award-number":["81960400"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Biochem &amp; Molecular Tox"],"published-print":{"date-parts":[[2022,7]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Chinese herbal medicine has well\u2010established therapeutic effects in various diseases. Corilagin (Cor), a gallic acid tannin in\n                    <jats:italic>Phyllanthus niruri<\/jats:italic>\n                    L., has anti\u2010inflammatory and antioxidant effects in many diseases. However, its role in osteoclast\u2010related bone diseases has not been determined. In vitro, bone marrow macrophages (BMMs) were extracted and isolated to differentiate into osteoclasts. The effects of Cor on osteoclast formation, bone resorption, and reactive oxygen species (ROS) production were performed. In addition, quantitative real\u2010time polymerase chain reaction and western blot analysis were used to evaluate the effect of Cor on oxidative stress\u2010related pathways, which are nuclear factors\u2010\u03baB ligand\u2010receptor activator (RANKL) stimulates important downstream pathways. Furthermore, microcomputed tomography and bone histomorphometry were performed to analyze the therapeutic effect of Cor in mouse models of lipopolysaccharide (LPS)\u2010mediated bone defects in vivo. Cor influenced the nuclear factor of activated T cells 1 (NFATc1) signaling pathway and reduced ROS in RANKL\u2010treated osteoclasts, thereby inhibiting osteoclast formation and bone resorption. Moreover, Cor protected against LPS\u2010mediated skull defects in vivo. In sum, our results confirm that Cor can inhibit osteoclastogenesis and intracellular oxidative stress. In addition, the inflammatory bone defect induced by LPS was also attenuated by Cor. Accordingly, Cor is a new candidate therapeutic agent for osteoclast\u2010mediated osteolytic diseases.\n                  <\/jats:p>","DOI":"10.1002\/jbt.23049","type":"journal-article","created":{"date-parts":[[2022,3,21]],"date-time":"2022-03-21T02:58:50Z","timestamp":1647831530000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Corilagin attenuates osteoclastic osteolysis by enhancing HO\u20101 and inhibiting ROS"],"prefix":"10.1002","volume":"36","author":[{"given":"Shaolin","family":"Tan","sequence":"first","affiliation":[{"name":"Department of Trauma Orthopedic and Hand Surgery The First Affiliated Hospital of Guangxi Medical University Nanning Guangxi China"},{"name":"Department of Orthopaedics The Second Affiliated Hospital of Guangxi Medical University Nanning Guangxi China"},{"name":"Guangxi Key Laboratory of Regenerative Medicine Guangxi Medical University Nanning Guangxi 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