{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,22]],"date-time":"2026-07-22T10:32:40Z","timestamp":1784716360511,"version":"3.55.0"},"reference-count":35,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2022,4,5]],"date-time":"2022-04-05T00:00:00Z","timestamp":1649116800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100007194","name":"Wenzhou Municipal Science and Technology Bureau","doi-asserted-by":"publisher","award":["Y2020083"],"award-info":[{"award-number":["Y2020083"]}],"id":[{"id":"10.13039\/501100007194","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Biochem &amp; Molecular Tox"],"published-print":{"date-parts":[[2022,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Cadmium (Cd) is an environmental pollutant and pregnant women are especially susceptible to the effects of exposure to Cd. Our previous study found Cd can be accumulated in the placenta and causes fetal growth restriction (FGR) through damage the placental glucocorticoid barrier. Selenium (Se), as an essential micronutrient, can allivate Cd\u2010induced toxicity. In this study, we aim to explore the protective mechanism of Se against Cd\u2010induced the placental glucocorticoid barrier damage and FGR. Pregnant Sprague Dawley (SD) rats were exposed to CdCl<jats:sub>2<\/jats:sub> (1\u2009mg\/kg\/day) and Na<jats:sub>2<\/jats:sub>SeO<jats:sub>3<\/jats:sub> (0.1\u20130.2\u20130.3\u2009mg\/kg\/day) by gavage from gestational day (GD) 0 to GD 19. The results showed that reduced fetal weight, increased corticosterone concentrations in the maternal and fetal serum, and impaired placental labyrinth layer blood vessel development, appeared in pregnant rats after Cd exposure and improved after treated with Se. In cell experiments, we confirmed that Se reduces Cd\u2010induced apoptosis. Moreover, Se can abolish Cd\u2010induced 11\u03b2\u2010HSD2 and specificity protein 1 (Sp1) decreasing in vivo and vitro. In human JEG\u20103 cells, the knockdown of Sp1 expression by small interfering RNA can suppressed the protective effect of Se on Cd\u2010induced 11\u03b2\u2010HSD2 decreasing. In general, our results demonstrated that Se is resistant to Cd\u2010induced FGR through upregulating the placenta barrier via activation of the transcription factor Sp1.<\/jats:p>","DOI":"10.1002\/jbt.23056","type":"journal-article","created":{"date-parts":[[2022,4,5]],"date-time":"2022-04-05T08:57:59Z","timestamp":1649149079000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Selenium attenuates the cadmium\u2010induced placenta glucocorticoid barrier damage by up\u2010regulating the expression of specificity protein 1"],"prefix":"10.1002","volume":"36","author":[{"given":"Sisi","family":"Wu","sequence":"first","affiliation":[{"name":"Departments of Obstetrics and Gynecology The Second Affiliated Hospital of Wenzhou Medical University Wenzhou Zhejiang China"},{"name":"The Second Clinical Medical College Wenzhou Medical University Wenzhou Zhejiang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Na","family":"Chen","sequence":"additional","affiliation":[{"name":"Departments of Obstetrics and Gynecology The Second Affiliated Hospital of Wenzhou Medical University Wenzhou Zhejiang China"},{"name":"The Second Clinical Medical College Wenzhou Medical University Wenzhou Zhejiang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xia","family":"Tong","sequence":"additional","affiliation":[{"name":"Departments of Obstetrics and Gynecology The Second Affiliated Hospital of Wenzhou Medical University Wenzhou Zhejiang China"},{"name":"The Second Clinical Medical College Wenzhou Medical University Wenzhou Zhejiang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xu","family":"Xu","sequence":"additional","affiliation":[{"name":"Departments of Obstetrics and Gynecology The Second Affiliated Hospital of Wenzhou Medical University Wenzhou Zhejiang China"},{"name":"The Second Clinical Medical College Wenzhou Medical University Wenzhou Zhejiang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qihui","family":"Chen","sequence":"additional","affiliation":[{"name":"Departments of Obstetrics and Gynecology The Second Affiliated Hospital of Wenzhou Medical University Wenzhou Zhejiang China"},{"name":"The Second Clinical Medical College Wenzhou Medical University Wenzhou Zhejiang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1583-1419","authenticated-orcid":false,"given":"Fan","family":"Wang","sequence":"additional","affiliation":[{"name":"Departments of Obstetrics and Gynecology The Second Affiliated Hospital of Wenzhou Medical University Wenzhou Zhejiang China"},{"name":"The Second Clinical Medical College Wenzhou Medical University Wenzhou Zhejiang China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,4,5]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.reprotox.2015.08.003"},{"key":"e_1_2_10_3_1","first-page":"263","volume":"8","author":"Apostoli P.","year":"2011","journal-title":"Met. 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