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Totally 25 Sprague\u2010Dawley rats were divided randomly into five groups: Control (orally received corn oil), DZN group (orally received 70\u2009mg\/kg\/day), and Res groups (received DZN 70\u2009mg\/kg\/day plus Res doses of 5, 10, and 20\u2009mg\/kg bodyweight\/\u2010day), respectively. DZN significantly inhibited serum acetylcholinesterase enzyme (Ach E), serum and liver catalase, glutathione peroxidase activities, also total antioxidant capacities. On the other hand, DZN increased serum and liver malondialdehyde. DZN significantly increased Forkhead box protein O1 (Foxo1) expression and decreased phosphatase and tensin homolog (PTEN) and sirtuin 1 (Sirt\u20101) expression. DZN impaired glucose hemostasis. Instead, Res treatment significantly reversed status of oxidative stress and antioxidant enzymes activities induced by DZN. Also, Res improved glucose hemostasis. Res increased PTEN and Sirt\u20101 expression and reduced Foxo1 expression. Res administration ameliorated liver histopathological changes induced by DZN. These data confirmed that DZN significantly enhances oxidative stress and impairs glucose hemostasis. While Res showed a protective effect against the toxicity induced by DZN in rats.<\/jats:p>","DOI":"10.1002\/jbt.23063","type":"journal-article","created":{"date-parts":[[2022,4,11]],"date-time":"2022-04-11T02:39:55Z","timestamp":1649644795000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["The protective effect of resveratrol on diazinon\u2010induced oxidative stress and glucose hemostasis disorder in rats' liver"],"prefix":"10.1002","volume":"36","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0106-245X","authenticated-orcid":false,"given":"Fereshteh","family":"Mehri","sequence":"first","affiliation":[{"name":"Department of Toxicology and Pharmacology, Nutrition Health Research Center Hamadan University of Medical Sciences Hamadan Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akram","family":"Ranjbar","sequence":"additional","affiliation":[{"name":"Department of Toxicology and Pharmacology, School of Pharmacy Hamadan University of Medical Sciences Hamadan Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naghmeh","family":"Shirafkan","sequence":"additional","affiliation":[{"name":"Department of Immunology Hamadan University of Medical Sciences Hamadan Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sara S.","family":"Asl","sequence":"additional","affiliation":[{"name":"Department of Anatomical Sciences, School of Medicine Endometrium and Endometriosis Research Center Hamadan University of Medical Sciences Hamadan Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maryam","family":"Esfahani","sequence":"additional","affiliation":[{"name":"Department of Toxicology and Pharmacology, Nutrition Health Research Center Hamadan University of Medical Sciences Hamadan Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,4,10]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pestbp.2006.06.011"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.3892\/br.2018.1090"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.5812\/ircmj.17(4)2015.25310"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/jat.761"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pestbp.2009.09.008"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tox.2012.11.002"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1177\/0748233712446726"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.toxrep.2018.10.014"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1155\/2012\/939751"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.chemosphere.2012.05.059"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00204-016-1849-x"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tem.2012.11.002"},{"issue":"2","key":"e_1_2_10_14_1","first-page":"237","volume":"16","author":"Kobayashi Y.","year":"2005","journal-title":"Int. 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