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To study whether paternal nicotine exposure influences acute liver injury and repair of the offspring, we established a paternal nicotine exposure model in mice and treated the offspring mice with carbon tetrachloride (CCl<jats:sub>4<\/jats:sub>) to induce acute liver injury. After the treatment of CCl<jats:sub>4<\/jats:sub>, the levels of alanine aminotransferase\u00a0and aspartate aminotransferase\u00a0in offspring serum of paternal nicotine exposed mice are about 37.44%, and 30.21% lower than the control mice, respectively. Transcription profiling screen and bioinformatics analysis of differently expressed genes in F1 mice liver revealed that the Wnt pathway was altered. The results demonstrate that nicotine exposure in male mice could enhance the activation of the Wnt pathway in F1 mice liver. The Wnt pathway facilitates cell proliferation and tissue repair. In conclusion, our findings showed that nicotine exposure of male mice protects hepatic against CCl<jats:sub>4<\/jats:sub>\u2010induced acute injury in offspring by activating the Wnt pathway in the F1 liver.<\/jats:p>","DOI":"10.1002\/jbt.23069","type":"journal-article","created":{"date-parts":[[2022,4,12]],"date-time":"2022-04-12T08:05:23Z","timestamp":1649750723000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Nicotine exposure of male mice protects offspring against carbon tetrachloride\u2010induced acute liver injury"],"prefix":"10.1002","volume":"36","author":[{"given":"Dong","family":"Zhang","sequence":"first","affiliation":[{"name":"School of Life Science and Biotechnology Shanghai Jiao Tong University Shanghai China"},{"name":"Shanghai Cancer Institute, Renji Hospital Shanghai Jiao Tong University School of Medicine Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingbo","family":"Dai","sequence":"additional","affiliation":[{"name":"Ann &amp; Robert H. 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