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The present study focused on the antioxidant and anti\u2010inflammatory effects of perindopril (PER) for the purpose of preventing the adverse effects of sepsis on the myocardium and developing new alternatives in treatment. The control group received only saline solution via the oral route for 4 days. The second group underwent cecal ligation puncture (CLP), and the third underwent CLP and received PER (2\u2009mg\/kg). Rats in the third group received 2\u2009mg\/kg PER per oral (p.o.) from 4 days before induction of sepsis. Thiobarbituric acid reactive species (TBARS), total thiol (\u2010SH), interleukin\u20101 beta (IL\u20101\u03b2), IL\u20106, 8\u2010hydroxy\u20102\u2032\u2010deoxyguanosine (8\u2010OHdG), and nuclear factor kappa B (NF\u2010\u03baB\/p65) levels increased in the CLP groups. In contrast, PER (2\u2009mg\/kg) decreased the levels of biochemical parameters other than total\u2010SH and decreased 8\u2010OHdG, NF\u2010\u03baB\/p65 immunopositivity in rat heart tissues. The data from this study show that impairment of the oxidant\/antioxidant balance and inflammatory cytokine levels in favor of inflammation in heart tissue under septic conditions results in severe tissue damage. PER administration before sepsis was shown to exhibit antioxidant and anti\u2010inflammatory properties by reducing these effects. This in turn increased the importance of PER as new evidence of its protective effects in heart tissue.<\/jats:p>","DOI":"10.1002\/jbt.23080","type":"journal-article","created":{"date-parts":[[2022,4,13]],"date-time":"2022-04-13T13:09:21Z","timestamp":1649855361000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["The cardioprotective effects of perindopril in a model of polymicrobial sepsis: The role of radical oxygen species and the inflammation pathway"],"prefix":"10.1002","volume":"36","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4730-5015","authenticated-orcid":false,"given":"Atilla","family":"Topcu","sequence":"first","affiliation":[{"name":"Department of Pharmacology, Faculty of Medicine Recep Tayyip Erdogan University Rize Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ugur","family":"Kostakoglu","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases 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