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The experimental strategies of MI were stimulated through the subcutaneous direction of ISO (85\u2009mg\/kg body weight) for 14 days. ISO\u2010directed models showed elevated heart rate levels\u00a0and cardiac markers (serum creatine kinase [CK], serum CK\u2010myocardial band, serum C\u2010reactive proteins, and plasma homocysteine); increased cardiac\u2010troponins\u2010T, and troponin\u2010I levels in both serum and myocardium. Moreover, we perceived that a higher level of lipid peroxidation molecules (thiobarbituric acid reactive substances and lipid hydroperoxides) reduced the antioxidant enzyme levels in plasma and heart tissue of ISO\u2010directed rats. However, geraniol treatment prevents ISO\u2010directed enhancement of the heart rate, cardiac and lipid peroxidative genes; reverted the blood pressure, and antioxidant status in ISO\u2010directed\u00a0rats. Furthermore, gene expression results revealed that geraniol treatment inhibited the mitogen\u2010activated\u00a0protein\u00a0kinase (MAPK) proteins, inflammatory responder (tumor necrosis factor\u2010\u03b1,\u00a0interleukin\u00a06, nuclear factor\u2010\u03baB), and cardiac fibrotic proteins (matrix metalloproteinase\u20102[MMP\u20102], MMP\u20109) in ISO directed rats. Prdx\u20101 is an antioxidant response element, and it can regulate all the antioxidant proteins and it scavenges harmful radicals. Therefore, enhanced Prdx\u20101 expression is considered to have a pivotal role in preventing cardiac infarction. In this study, an elevated expression of Prdx1 was noticed in geraniol treated with ISO\u2010directed rats. Hence, we concluded that geraniol is considered a potential phytodrug, and it prevents ISO\u2010directed MAPKs, inflammation, and cardiac markers by enhancing the expression of Prdx1.<\/jats:p>","DOI":"10.1002\/jbt.23098","type":"journal-article","created":{"date-parts":[[2022,5,24]],"date-time":"2022-05-24T13:41:01Z","timestamp":1653399661000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":20,"title":["Geraniol enhances peroxiredoxin\u20101, and prevents isoproterenol\u2010induced oxidative stress\u00a0and inflammation associated with myocardial infarction in experimental animal models"],"prefix":"10.1002","volume":"36","author":[{"given":"Gangqiang","family":"Zou","sequence":"first","affiliation":[{"name":"Department of Macrovascular Surgery Fuwai Central China Cardiovascular Hospital Zhengzhou Henan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5811-4866","authenticated-orcid":false,"given":"Jia","family":"Wan","sequence":"additional","affiliation":[{"name":"Department of Vascular Surgery The Second People's Hospital of Yunnan Province Kunming Yunnan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Agilan","family":"Balupillai","sequence":"additional","affiliation":[{"name":"Department of Biotechnology Thiruvalluvar University Vellore Tamil Nadu India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ernest","family":"David","sequence":"additional","affiliation":[{"name":"Department of Biotechnology Thiruvalluvar University Vellore Tamil Nadu India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Babujanarthanam","family":"Ranganathan","sequence":"additional","affiliation":[{"name":"Department of Biotechnology Thiruvalluvar University Vellore Tamil Nadu India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kalaimani","family":"Saravanan","sequence":"additional","affiliation":[{"name":"Department of Biotechnology Thiruvalluvar University Vellore Tamil Nadu India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,5,24]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ssmph.2019.100365"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0027-5107(02)00324-X"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.3923\/tmr.2007.61.71"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.00054.2009"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu11092090"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2018.01162"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/acel.12322"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cardiores.2005.12.002"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.4161\/cc.8.24.10242"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1590\/1414-431x20144142"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/jcmm.12955"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.4103\/0976-500X.64533"},{"key":"e_1_2_8_14_1","doi-asserted-by":"crossref","first-page":"e22906","DOI":"10.1002\/jbt.22906","volume":"35","author":"Abukhali M. 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