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Cysteine and glycine\u2010rich protein 2 (Csrp2) has been reported to promote cell proliferation and migration, and affect cell cycle progression. As a new invasive actin\u2010binding factor, Csrp2 increased the invasion and even metastasis of some cancer cells. It was associated with tumor recurrence and chemotherapy resistance. However, the role of Csrp2 in PH remains unknown. We found that Csrp2 expression was increased both in pulmonary arteries (PAs) and smooth muscle cells (PASMCs) in PH. Csrp2 enhanced PASMC proliferation and phenotypic transition. The Wnt3\u03b1\u2010\u03b2\u2010catenin\/lymphoid enhancer\u2010binding factor 1 (LEF1) pathway is involved in cell proliferation and phenotypic transition regulated by Csrp2 expression. These results suggest that hypoxia downregulates YinYang\u20101 (YY1) and then increases Csrp2 expression. Increased Csrp2 promotes PASMC proliferation and phenotypic transition by activating the Wnt3\u03b1\u2010\u03b2\u2010catenin\/LEF1 pathways, which leads to pulmonary vascular remodeling and even provides a new theoretical basis for studying the pathogenesis and therapeutic targets of PH.<\/jats:p>","DOI":"10.1002\/jbt.23122","type":"journal-article","created":{"date-parts":[[2022,6,13]],"date-time":"2022-06-13T11:29:59Z","timestamp":1655119799000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Cysteine and glycine\u2010rich protein 2 promotes hypoxic pulmonary vascular smooth muscle cell proliferation through the Wnt3\u03b1\u2010\u03b2\u2010catenin\/lymphoid enhancer\u2010binding factor 1\u00a0pathway"],"prefix":"10.1002","volume":"36","author":[{"given":"Liyu","family":"Tang","sequence":"first","affiliation":[{"name":"Department of Cardiac Surgery Fujian Medical University Union Hospital  Fuzhou China"},{"name":"Department of Physiology and Pathophysiology The Key Laboratory of Fujian Province Universities on Ion Channel and Signal Transduction in Cardiovascular Diseases, The School of Basic Medical Sciences, Fujian Medical University  Fuzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nan","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Cardiac Surgery Fujian Medical University Union Hospital  Fuzhou China"},{"name":"Department of Physiology and Pathophysiology The Key Laboratory of Fujian Province Universities on Ion Channel and Signal Transduction in Cardiovascular Diseases, The School of Basic Medical Sciences, Fujian Medical University  Fuzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaozhen","family":"Wei","sequence":"additional","affiliation":[{"name":"Department of Physiology and Pathophysiology The Key Laboratory of Fujian Province Universities on Ion Channel and Signal Transduction in Cardiovascular Diseases, The School of Basic Medical Sciences, Fujian Medical University  Fuzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sirui","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Physiology and Pathophysiology The Key Laboratory of Fujian Province Universities on Ion Channel and Signal Transduction in Cardiovascular Diseases, The School of Basic Medical Sciences, Fujian Medical University  Fuzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pan","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Physiology and Pathophysiology The Key Laboratory of Fujian Province Universities on Ion Channel and Signal Transduction in Cardiovascular Diseases, The School of Basic Medical Sciences, Fujian Medical University  Fuzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yameng","family":"Zheng","sequence":"additional","affiliation":[{"name":"Department of Physiology and Pathophysiology The Key Laboratory of Fujian Province Universities on Ion Channel and Signal Transduction in Cardiovascular Diseases, The School of Basic Medical Sciences, Fujian Medical University  Fuzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liangwan","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Cardiac Surgery Fujian Medical University Union Hospital  Fuzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8355-7979","authenticated-orcid":false,"given":"Li","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Cardiac Surgery Fujian Medical University Union Hospital  Fuzhou China"},{"name":"Department of Physiology and Pathophysiology The Key Laboratory of Fujian Province Universities on Ion Channel and Signal Transduction in Cardiovascular Diseases, The School of Basic Medical Sciences, Fujian Medical University  Fuzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,6,13]]},"reference":[{"issue":"13","key":"e_1_2_8_2_1","first-page":"14171431","volume":"114","author":"McLaufhlin V. 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