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A total of 22 female Sprague\u2013Dawley rats were randomly divided into four groups as follows: Group I (<jats:italic>n<\/jats:italic>\u2009=\u20095), intact animals; Group II (<jats:italic>n<\/jats:italic>\u2009=\u20096), animals received 50\u2009mg\/kg\/day of MMSC by gavage technique for 3 consecutive days; Group III (<jats:italic>n<\/jats:italic>\u2009=\u20095), animals injected with a single dose of 500\u2009mg\/kg of GalN intraperitoneally (ip); and Group IV (<jats:italic>n<\/jats:italic>\u2009=\u20096), animals injected with the same dose of GalN 1\u2009h after MMSC treatment. After 6\u2009h of the last GalN treatment (at the end of the experiments), all animals were killed under anesthesia, brain and cerebellum tissues were dissected out. Reduced glutathione, total antioxidant status levels, and antioxidant enzymes (catalase, superoxide dismutase, and glutathione\u2010related enzymes), aryl esterase, and carbonic anhydrase activities remarkably declined whereas advanced oxidized protein products, reactive oxygen species, total oxidant status, oxidative stress index levels, and myeloperoxidase, acetylcholinesterase, lactate dehydrogenase, and xanthine oxidase activities were significantly elevated in the GalN group compared with intact rats. In contrast, the administration of MMSC to GalN groups reversed these alterations. In conclusion, we may suggest that MMSC has protective effects against GalN\u2010induced brain and cerebellar toxicity in rats.<\/jats:p>","DOI":"10.1002\/jbt.23126","type":"journal-article","created":{"date-parts":[[2022,6,8]],"date-time":"2022-06-08T08:21:14Z","timestamp":1654676474000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Oxidative brain and cerebellum injury induced by<scp>d<\/scp>\u2010galactosamine: Protective effect of<i>S<\/i>\u2010methyl methionine sulfonium chloride"],"prefix":"10.1002","volume":"36","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2536-0315","authenticated-orcid":false,"given":"Dastagul","family":"Mahmarzayeva","sequence":"first","affiliation":[{"name":"Department of Chemistry, Faculty of Engineering Istanbul University\u2010Cerrahpa\u015fa Avcilar Istanbul Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0700-5096","authenticated-orcid":false,"given":"Bertan Boran","family":"Bayrak","sequence":"additional","affiliation":[{"name":"Department of Chemistry, Faculty of Engineering Istanbul University\u2010Cerrahpa\u015fa Avcilar Istanbul Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2789-5943","authenticated-orcid":false,"given":"Ismet Burcu","family":"Turkyilmaz","sequence":"additional","affiliation":[{"name":"Department of Chemistry, Faculty of Engineering Istanbul University\u2010Cerrahpa\u015fa Avcilar Istanbul Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6503-4613","authenticated-orcid":false,"given":"Ozlem","family":"Sacan","sequence":"additional","affiliation":[{"name":"Department of Chemistry, Faculty of Engineering Istanbul University\u2010Cerrahpa\u015fa Avcilar Istanbul Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4185-4363","authenticated-orcid":false,"given":"Refiye","family":"Yanardag","sequence":"additional","affiliation":[{"name":"Department of Chemistry, Faculty of Engineering Istanbul University\u2010Cerrahpa\u015fa Avcilar Istanbul Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,6,8]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-323-90583-1.00007-6"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v27.i7.592"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.5152\/EurJBiol.2017.1703"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/tox.23073"},{"key":"e_1_2_10_6_1","unstructured":"A.Rouf A. 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