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More effective treatment methods with less side effects need to be developed. In this context, current study investigated the therapeutic effects of safranal in a model of complete Freund's adjuvant (CFA)\u2010induced RA. The control group was given 1\u2009ml of saline orally starting from the 8th day, and 0.2\u2009ml of CFA was given to the RA, RA\u2009+\u2009Safranal and RA\u2009+\u2009Methotrexate (MTX) groups on the 0th day of the experiment. Starting from the 8th day of the experiment, 1\u2009ml of saline was given to the RA group, safranal was given at 200\u2009mg\/kg of body weight to the RA\u2009+\u2009MTX group, and 3\u2009mg\/kg of MTX to the RA\u2009+\u2009MTX group twice a week. The results showed that weight gain decreased in the RA group compared to the control group while arthritis index score, thymus index, and planter temperature were found to be increased. Additionally, a deterioration in blood parameters, an increase in alanine aminotransferase, aspartate aminotransferase, urea, creatinine, C\u2010reactive protein, and malondialdehyde levels, and a decrease in reduced glutathione levels and glutathione peroxidase and catalase (CAT) activities were seen while tumor necrosis factor\u2010\u03b1, interleukin\u20106 (IL\u20106), cyclooxygenase\u20102, nuclear factor kappa B levels were found to be increased. However, the safranal had a regulatory effect on all the values, except IL\u20106 and CAT, and blood parameters. Moreover, histopathological examination revealed that safranal reduced inflammatory cell infiltration and edema.<\/jats:p>","DOI":"10.1002\/jbt.23140","type":"journal-article","created":{"date-parts":[[2022,6,8]],"date-time":"2022-06-08T08:35:46Z","timestamp":1654677346000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Investigation of the effects of safranal on the experimentally created rheumatoid arthritis model in rats"],"prefix":"10.1002","volume":"36","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2559-096X","authenticated-orcid":false,"given":"Mustafa","family":"Cellat","sequence":"first","affiliation":[{"name":"Department of Physiology, Faculty of Veterinary Medicine Hatay Mustafa Kemal University  Hatay T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1910-8316","authenticated-orcid":false,"given":"Cafer 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