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Hydroquinone (HQ) is the main metabolite of benzene, one of the important environmental factors contributing to leukemia and lymphoma. In HQ\u2010induced malignant transformed TK6 (TK6\u2010HT) cells, the expression of PARP\u20101 and miR\u2010223 were upregulated. When in PARP\u20101 silencing TK6\u2010HT cells, miR\u2010223 was downregulated and the apoptotic cell number correspondingly increased. In TK6 cells treated with HQ for different terms, the expression of miR\u2010223 and PARP\u20101 were dynamically observed and found to be decreased and increased, respectively. Trichostatin A could increase the expression of miR\u2010223, then the expression of HDAC1\u20132 and nuclear factor kappa B were found to be increased, but that of mH2A was decreased. PARP\u20101 silencing inhibited the protein expression of H3Ac, mH2A, and H3K27ac. By co\u2010immunoprecipitation experiment, PARP\u20101 and HDAC2 were found to form a regulatory complex. In conclusion, we demonstrated that the upregulation of PARP\u20101 mediated activation of acetylation to promote the transcription of miR\u2010223 possibly via coregulating with HDAC2, an epigenetic regulation mechanism involved in cell malignant transformation resulting from long\u2010term exposure to HQ, in which course, H3K27ac might be a specific marker for the activation of histone H3, which also gives hints for benzene exposure research.<\/jats:p>","DOI":"10.1002\/jbt.23142","type":"journal-article","created":{"date-parts":[[2022,6,14]],"date-time":"2022-06-14T07:25:34Z","timestamp":1655191534000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["PARP\u20101 modulates the expression of miR\u2010223 through histone acetylation to involve in the hydroquinone\u2010induced carcinogenesis of TK6 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