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The main purpose of this study is to assess the cardiopreventive effects of BeG (50\u2009mg\/kg) in isoproterenol (ISO)\u2010induced MI in Wistar rats. The increased infarct size after ISO induction was reduced simultaneously on treatment with BeG. Similarly, augmented levels of cardiac biomarkers, namely cardiac troponin T, creatine kinase (CK), cardiac troponin I, and CK\u2010MB were also suppressed by BeG. The increased rate of lipid hydroperoxides\u00a0and thiobarbituric acid reactive substances owing\u00a0to the oxidative stress caused by free radical generation in ISO\u2010induced\u00a0rats were also inhibited by BeG. Antioxidants reduce oxidative stress by scavenging free radicals. ISO induction reduces these antioxidant enzymes glutathione peroxidase, catalase, superoxide dismutase, and glutathione, and\u00a0levels causing oxidative cardiac damage to the heart tissue. BeG supplementation improved these enzymes synthesis preventing potential damage to the myocardium. Inflammation caused by ISO pretreatment increased the secretion of proinflammatory cytokines in ISO\u2010induced\u00a0rats. Pretreatment with BeG suppressed these inflammatory cytokines to a normal level in ISO\u2009+\u2009BeG\u2010treated rats. The histopathological examination of the morphological characteristics showed that the intensity of cardiac damage caused by ISO induction was less in BeG pretreated rats with less inflammatory cells and no necrosis. BeG also showed promising results in the molecular alteration of AMP\u2010activated protein kinase\/endothelial\u00a0nitric oxide synthase\/protein kinase B signaling molecules. These observations emphasize the cardioprotective effects of BeG and its potential use as a drug in the near future.<\/jats:p>","DOI":"10.1002\/jbt.23143","type":"journal-article","created":{"date-parts":[[2022,7,11]],"date-time":"2022-07-11T10:34:52Z","timestamp":1657535692000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Bergapten mediated inflammatory and apoptosis through AMPK\/eNOS\/AKT signaling pathway of isoproterenol\u2010induced myocardial infarction in Wistar rats"],"prefix":"10.1002","volume":"36","author":[{"given":"Yanni","family":"Yang","sequence":"first","affiliation":[{"name":"Department of Cardiology Digital Subtraction Angiography (DSA) Xi'an International Medical Center Hospital Xi'an China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juanping","family":"Han","sequence":"additional","affiliation":[{"name":"Department of Cardiology Xi'an International Medical Center Hospital Xi'an China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Renju G.","family":"Lilly","sequence":"additional","affiliation":[{"name":"Department of Biochemistry University of Kerala, Palayam Thiruvananthapuram Kerala India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2665-0859","authenticated-orcid":false,"given":"Qin","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Cardiology Digital Subtraction Angiography (DSA) Xi'an International Medical Center Hospital Xi'an China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8127-7834","authenticated-orcid":false,"given":"Yanjie","family":"Guo","sequence":"additional","affiliation":[{"name":"Department of Cardiology Xi'an International Medical Center Hospital Xi'an China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,7,11]]},"reference":[{"key":"e_1_2_9_2_1","first-page":"186","volume":"31","author":"Felaco A. 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