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The introduced nano\u2010drug delivery system was exerted to perform an in vitro treatment on CT\u201026 mouse colorectal cancer cells. The synthesized final product was labeled as 5\u2010FU@CuS\/NH<jats:sub>2<\/jats:sub>\u2010UiO\u201066 and characterized through conventional methods including X\u2010ray diffraction (XRD), Fourier transformation infrared spectroscopy (FT\u2010IR), Brunauer\u2013Emmett\u2013Teller (BET) analysis, Ultraviolet\u2010Visible (UV\u2010Vis) analysis, Inductively coupled plasma mass spectrometry (ICP\u2010MS), and 3\u2010(4,5\u2010dimethylthiazol\u20102\u2010yl)\u22122,5\u2010diphenyltetrazolium bromide (MTT) assay. 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