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However, recent evidence indicates the lack of effective treatments for HF. Hesperetin, a Traditional Chinese Medicine monomer, has been isolated from the fruit peel of <jats:italic>Citrusaurantium L. (Rutaceae)<\/jats:italic>. Growing evidence suggests the partial function of hesperetin in HF treatment. A hesperetin derivative (HD) was synthesized in our laboratory to increase the bioavailability and the water solubility of hesperetin. In this study, we detected the functions of HD in a mouse model of CCl<jats:sub>4<\/jats:sub>\u2010induced HF and transforming growth factor\u2010\u03b21\u2010stimulated HSC\u2010T6 cells, in vivo and in vitro. HD\u00a0reduced histological damage and CCl<jats:sub>4<\/jats:sub>\u2010induced HF. Moreover, HD interference was associated with the activation of indicators in HSC\u2010T6 cells, showing that HD is involved in HSCs activation in HF. Mechanistically, the Hedgehog pathway is involved in the HD treatment of HF, and HD may attenuate the aberrant expression of patched1. In conclusion, the studies indicate that HD may function as a potential antifibrotic Traditional Chinese Medicine monomer in HF therapy.<\/jats:p>","DOI":"10.1002\/jbt.23149","type":"journal-article","created":{"date-parts":[[2022,6,17]],"date-time":"2022-06-17T07:15:20Z","timestamp":1655450120000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Hesperetin derivative decreases CCl<sub>4<\/sub>\u2010induced hepatic fibrosis by Ptch1\u2010dependent mechanisms"],"prefix":"10.1002","volume":"36","author":[{"given":"Sai","family":"Zhu","sequence":"first","affiliation":[{"name":"School of Pharmacy, Anhui Medical University, Inflammation and Immune Mediated Diseases Laboratory of Anhui Province Anhui Institute of Innovative Drugs Hefei China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xin","family":"Chen","sequence":"additional","affiliation":[{"name":"School of Pharmacy, Anhui Medical University, 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