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MicroRNA (miR)\u2212506 was reported to participate in breast cancer progression, while the role of miR\u2010506 in breast cancer\u2010induced osteolytic bone metastasis is unclear. In the present study, we found significant downregulation of miR\u2010506 in breast cancer tissues and cell lines. Overexpression of miR\u2010506 notably reduced the proliferative, migratory and invasive rates of MCF7 and MDA\u2010MB\u2010231 cells, and reduced the production of inflammatory factors IL\u20106 and TNF\u2010\u03b1 in MCF7 cells. Moreover, overexpression of miR\u2010506 obviously inhibited tumor growth in an in vivo animal model. In addition, overexpression of miR\u2010560 efficiently attenuated breast cancer\u2010induced osteolysis in vivo, which was characterized by increased bone volume\/total volume (BT\/TV), trabecular number (Tb. N), and trabecular thickness (Tb. Th), as well as the reduced trabecular separation (Tb. Sp). The nuclear factor of activated T cell cytoplasmic 1 (NFATc1) was identified as a downstream target of miR\u2010506, and overexpression of miR\u2010506 could inhibit breast cancer progression by targeting NFATc1. Furthermore, our results showed that NFATc\u20101 might participate in the inhibition of miR\u2010506 on breast cancer\u2010induced osteolysis. In conclusion, our findings provide insights into understanding the pathogenesis of breast cancer and breast cancer\u2010induced osteolytic bone metastasis, and miR\u2010506 might serve as a novel biomarker for this disease.<\/jats:p>","DOI":"10.1002\/jbt.23156","type":"journal-article","created":{"date-parts":[[2022,9,26]],"date-time":"2022-09-26T09:36:12Z","timestamp":1664184972000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["MicroRNA\u2010506 ameliorates breast cancer\u2010induced osteolytic bone metastasis via the NFATc\u20101 signaling pathway"],"prefix":"10.1002","volume":"36","author":[{"given":"Feng","family":"Lv","sequence":"first","affiliation":[{"name":"Department of Breast Surgery Henan Provincial People's Hospital (Henan University People's Hospital) Zhengzhou City Henan Province China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingbo","family":"Qin","sequence":"additional","affiliation":[{"name":"Department of Breast Surgery Henan Provincial People's Hospital (Henan University People's Hospital) Zhengzhou City Henan Province China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuxin","family":"Kong","sequence":"additional","affiliation":[{"name":"Department of Breast Surgery Henan Provincial People's Hospital (Henan University People's Hospital) Zhengzhou City Henan Province China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Limin","family":"Pan","sequence":"additional","affiliation":[{"name":"Department of Breast Surgery Henan Provincial People's Hospital (Henan University People's Hospital) Zhengzhou City Henan Province China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6870-5646","authenticated-orcid":false,"given":"Ran","family":"Ding","sequence":"additional","affiliation":[{"name":"Orthopedic Surgery of Wuhan General Hospital of People's Liberation Army Wuhan City Hubei Province China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,9,26]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21262"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.3389\/fpsyg.2021.769394"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1101\/cshperspect.a031229"},{"key":"e_1_2_12_5_1","first-page":"1","volume":"102","author":"Christiansen P.","year":"2001","journal-title":"APMIS Suppl."},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.1210\/er.2010-0006"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.3390\/cancers12020326"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.11005\/jbm.2014.21.4.233"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bone.2006.09.023"},{"key":"e_1_2_12_10_1","first-page":"6","volume":"6","author":"Wu A. 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