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Exposure to methylmercury, a highly toxic organic compound, causes important neurological and developmental impairments. Recently, the genotoxicity of mercurial compounds has gained prominence as one of the possible mechanisms associated with the neurological effects of mercury, mostly by disturbing the mitotic spindle and causing chromosome loss. In this sense, it is important to investigate if these compounds can also cause direct damage to DNA, such as single and double\u2010strand breaks. Thus, the aim of this study was to investigate the cytotoxic and genotoxic potential of methylmercury in cell lines derived from neurons (B103) and glia (C6), exposed to methylmercury (MeHg) for 24\u2009h, by analyzing cell viability, metabolic activity, and damage to DNA and chromosomes. We found that in comparison to the neuronal cell line, glial cells showed higher tolerance to MeHg, and therefore a higher LC<jats:sub>50<\/jats:sub> and consequent higher intracellular accumulation of Hg, which led to the occurrence of several genotoxic effects, as evidenced by the presence of micronuclei, bridges, sprouts, and chromosomal aberrations.<\/jats:p>","DOI":"10.1002\/jbt.23170","type":"journal-article","created":{"date-parts":[[2022,7,13]],"date-time":"2022-07-13T11:10:15Z","timestamp":1657710615000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Intracellular accumulation and DNA damage caused by methylmercury in glial cells\u00a0"],"prefix":"10.1002","volume":"36","author":[{"given":"Aline H.","family":"Sousa","sequence":"first","affiliation":[{"name":"Programa de P\u00f3s Gradua\u00e7\u00e3o em Epidemiologia e vigil\u00e2ncia em Sa\u00fade Instituto Evandro Chagas  Ananindeua Par\u00e1 Brazil"},{"name":"Se\u00e7\u00e3o de Bacteriologia Instituto Evandro Chagas  Ananindeua Par\u00e1 Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jo\u00e3o P. 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