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The current study was conducted to investigate the protective action of <jats:italic>Fumaria officinalis<\/jats:italic> against PER\u2010induced liver injury in male rats. However, HPLC\u2010DAD showed the richness of 6 components in <jats:italic>F. officinalis<\/jats:italic> (F) including quercetin, ferulic acid, and naringenin which were the most abundant. Total polyphenols, total flavonoids, and condensed tannins were studied by phytochemical screening. In vitro, antioxidant properties showed that <jats:italic>F. officinalis<\/jats:italic> exhibited the highest DPPH radical, FRAP, and H<jats:sub>2<\/jats:sub>O<jats:sub>2<\/jats:sub> tests and total antioxidant capacity. Wistar rats were divided into four groups: negative control group (C), positive control group (F) (200\u2009mg <jats:italic>F<\/jats:italic>. <jats:italic>officinalis<\/jats:italic>\/kg BW), PER group (34.05\u2009mg permethrin\/kg BW), and PER\u2009+\u2009F group (34.05\u2009mg permethrin\/kg BW and 200\u2009mg\u00a0<jats:italic>F<\/jats:italic>. <jats:italic>officinalis<\/jats:italic>\/kg BW). Oral administration of PER led to promote a decrease of body weight and Ca<jats:sup>2+<\/jats:sup>\u2010ATPases and Mg<jats:sup>2+<\/jats:sup>\u2010ATPases activities and an increase of plasma C\u2010reactive protein\u00a0level, transaminases, and hepatic \u03d2\u2010GT activities as well as hepatic and mitochondrial oxidative stress. An increase in plasma lactate\u2010to pyruvate ratio and a reduction in complexes enzymes I, III, and IV activities were also observed. In addition, histoarchitecture of liver in PER\u2010treated\u00a0rats showed apoptosis and necrosis as confirmed by DNA fragmentation. <jats:italic>F. officinalis<\/jats:italic> significantly exerted hepatoprotective effect by modulating hepatic alteration and mitochondrial dysfunction as well as genotoxicity. This effect could be attributed to phenolics compounds such as polyphenols, condensed tannins, and flavonoids.<\/jats:p>","DOI":"10.1002\/jbt.23172","type":"journal-article","created":{"date-parts":[[2022,7,21]],"date-time":"2022-07-21T14:39:22Z","timestamp":1658414362000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["RETRACTED: The pyrethroid insecticide permethrin confers hepatotoxicity through DNA damage and mitochondria\u2010associated apoptosis induction in rat: Palliative benefits of <i>Fumaria\u00a0officinalis<\/i>"],"prefix":"10.1002","volume":"36","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2945-1668","authenticated-orcid":false,"given":"Nissaf","family":"Aoiadni","sequence":"first","affiliation":[{"name":"Laboratory of Animal Eco\u2010Physiology, Faculty of Sciences of Sfax University of Sfax  Sfax Tunisia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nour","family":"Chiab","sequence":"additional","affiliation":[{"name":"Laboratory of Plant improvement and Agri\u2010Resources Valorization, National School of Engineers of Sfax (ENIS) University of Sfax  Sfax Tunisia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hajer","family":"Jdidi","sequence":"additional","affiliation":[{"name":"Laboratory of Animal Eco\u2010Physiology, Faculty of Sciences of Sfax University of Sfax  Sfax Tunisia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Radhia","family":"Gargouri Bouzid","sequence":"additional","affiliation":[{"name":"Laboratory of Plant improvement and Agri\u2010Resources Valorization, National School of Engineers of Sfax (ENIS) University of Sfax  Sfax Tunisia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abdelfattah","family":"El Feki","sequence":"additional","affiliation":[{"name":"Laboratory of Animal Eco\u2010Physiology, Faculty of Sciences of Sfax University of Sfax  Sfax Tunisia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hamadi","family":"Fetoui","sequence":"additional","affiliation":[{"name":"Laboratory of Toxicology and Environmental Health (LR17ES06), Sciences Faculty of Sfax University of Sfax  Sfax Tunisia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fatma\u00a0","family":"Ghorbel Koubaa","sequence":"additional","affiliation":[{"name":"Laboratory of Animal Eco\u2010Physiology, Faculty of Sciences of Sfax University of Sfax  Sfax Tunisia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,7,21]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/jemt.21047"},{"key":"e_1_2_10_3_1","first-page":"789","volume":"81","author":"Roberts D. 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