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Relevant published literature reviews, studies, and clinical trials were accessed from institutional and electronic databases. The keywords used were respiratory diseases, steroids, antibiotics, and combination of steroids and antibiotics. Selected articles and literature were carefully reviewed. Antibiotics are often prescribed as the standard therapy to manage RDs. Types of causative respiratory pathogens, spectrum of antibiotics activity, route of administration, and course of therapy determine the type of antibiotics that are prescribed. Despite being associated with good clinical outcome, treatment failure and recurrence rate are still high. In addition, antibiotic resistance has been widely reported due to bacterial mutations in response to the use of antibiotics, which render them ineffective. Nevertheless, there has been a growing demand for corticosteroids (CS) and antibiotics to treat a wide variety of diseases, including various airway diseases, due to their immunosuppressive and anti\u2010inflammatory properties. The use of CS is well established and there are different formulations based on the diseases, such as topical administration, tablets, intravenous injections, and inhaled preparations. Both antibiotics and CS possess similar properties in terms of their anti\u2010inflammatory effects, especially\u00a0regulating cytokine release. Thus, the current review examines and discusses the different applications of antibiotics, CS, and their combination in managing various RDs. Drawbacks of these interventions are also discussed.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jbt.23174","type":"journal-article","created":{"date-parts":[[2022,7,21]],"date-time":"2022-07-21T14:20:31Z","timestamp":1658413231000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Exploring the role of antibiotics and steroids in managing respiratory diseases"],"prefix":"10.1002","volume":"36","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0013-8662","authenticated-orcid":false,"given":"Dinesh K.","family":"Chellappan","sequence":"first","affiliation":[{"name":"Department of Life Sciences International Medical University  Bukit Jalil Kuala Lumpur Malaysia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Parteek","family":"Prasher","sequence":"additional","affiliation":[{"name":"Department of Chemistry University of Petroleum and Energy Studies  Dehradun 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