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Our research aimed to study the exact mechanism of hepatotoxicity induced by isotretinoin and the protective role of taurine in this toxicity. Biomarkers such as aspartate transaminase (AST) and alanine transaminase (ALT), superoxide dismutase, glutathione content (GSH), catalase,\u00a0and malondialdehyde (MDA) were examined. Furthermore, pathological changes were evaluated. The results showed that oral administration of Isotretinoin induced hepatotoxicity as showed by elevation in ALT, AST, and MDA; also, it reduced intracellular GSH in rat liver tissue. Administration of taurine prevented the hepatotoxicity induced by isotretinoin in rats significantly.<\/jats:p>","DOI":"10.1002\/jbt.23178","type":"journal-article","created":{"date-parts":[[2022,7,30]],"date-time":"2022-07-30T10:51:25Z","timestamp":1659178285000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["The hepatoprotective effects of taurine against oxidative stress induced by isotretinoin in rats"],"prefix":"10.1002","volume":"36","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8307-2944","authenticated-orcid":false,"given":"Shohreh","family":"Taziki","sequence":"first","affiliation":[{"name":"Department of Pharmacology &amp; Toxicology, Ischemic Disorder Research Center Golestan University of Medical Sciences and Health  Gorgan Golestan Iran"},{"name":"Department of Pharmacology &amp; Toxicology, Faculty of Medicine Golestan University of Medical Sciences and Health  Gorgan Golestan Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Faramarz","family":"Gholamzadeh","sequence":"additional","affiliation":[{"name":"Department of Pharmacology &amp; Toxicology, Ischemic Disorder Research Center Golestan University of Medical Sciences and Health  Gorgan Golestan Iran"},{"name":"Department of Pharmacology &amp; Toxicology, Faculty of Medicine Golestan University of Medical Sciences and Health  Gorgan Golestan Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rozhin","family":"Hosseini","sequence":"additional","affiliation":[{"name":"Department of Pharmacology &amp; Toxicology, Ischemic Disorder Research Center Golestan University of Medical Sciences and Health  Gorgan Golestan Iran"},{"name":"Department of Pharmacology &amp; Toxicology, Faculty of Medicine Golestan University of Medical Sciences and Health  Gorgan Golestan Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,7,30]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/jbt.21542"},{"key":"e_1_2_9_3_1","first-page":"5","volume":"74","author":"Heidelbaugh J. 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