{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T18:17:11Z","timestamp":1792088231859,"version":"4.4.0"},"reference-count":34,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2022,8,4]],"date-time":"2022-08-04T00:00:00Z","timestamp":1659571200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Biochem &amp; Molecular Tox"],"published-print":{"date-parts":[[2022,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The present study investigated the relationship between <jats:italic>MLH1, MSH2, MSH3<\/jats:italic>, and <jats:italic>MSH6<\/jats:italic> polymorphisms and toxicity due to platinum\u2010based doublet chemotherapy for North Indian lung cancer patients. Polymerase chain reaction\u2010restriction fragment length polymorphism technique was used to assess the polymorphism. For <jats:italic>MSH2 IVS1<\/jats:italic>\u2009+\u2009<jats:italic>9G<\/jats:italic>\u2009&gt;\u2009<jats:italic>C<\/jats:italic> polymorphism variant type genotype reported a 1.4\u2010fold increased risk of anemia (AOR\u2009=\u20091.4; 95% CI\u2009=\u20090.98\u20131.99; <jats:italic>p<\/jats:italic>\u2009=\u20090.04) and decreased risk of developing gastrointestinal toxicity (diarrhea) (AOR\u2009=\u20090.53; 95%\u00a0CI\u2009=\u20090.28\u20131.01; <jats:italic>p<\/jats:italic>\u2009=\u20090.04). Further, we also reported a 10\u2010fold increased risk of developing severe grade anorexia in combined genotype (<jats:italic>GC<\/jats:italic>\u2009+\u2009<jats:italic>CC<\/jats:italic>) (AOR\u2009=\u20099.18; 95%\u00a0CI\u2009=\u20090.98\u201386.1; <jats:italic>p<\/jats:italic>\u2009=\u20090.05). For <jats:italic>MSH2 T<\/jats:italic>\u2009&gt;\u2009<jats:italic>C\/\u20106<\/jats:italic> polymorphism, variant type reported a 3\u2010fold and 2\u2010fold increased risk of developing severe grade leukopenia (AOR\u2009=\u20093.37; 95%\u00a0CI\u2009=\u20091.44\u20137.88; <jats:italic>p<\/jats:italic>\u2009=\u20090.005) and neutropenia respectively (AOR\u2009=\u20092.23; 95%\u00a0CI\u2009=\u20091.07\u20134.66; <jats:italic>p<\/jats:italic>\u2009=\u20090.03). For <jats:italic>MSH3 G<\/jats:italic>\u2009&gt;\u2009<jats:italic>A<\/jats:italic> polymorphism, heterozygous (<jats:italic>GA<\/jats:italic>) and combined genotype (<jats:italic>GA<\/jats:italic>\u2009+\u2009<jats:italic>AA<\/jats:italic>) reported a 7\u2010fold and 6\u2010fold increased risk of developing anemia (AOR\u2009=\u20097.23; 95%\u00a0CI\u2009=\u20091.51\u201334.6; <jats:italic>p<\/jats:italic>\u2009=\u20090.01, AOR\u2009=\u20096.39; 95%\u00a0CI\u2009=\u20091.53\u201326.6; <jats:italic>p<\/jats:italic>\u2009=\u20090.01). Our results suggest that polymorphisms in DNA mismatch repair genes are associated with hematological, and gastrointestinal toxicities and might be considered a predictor for pretreatment evaluation in lung cancer patients.<\/jats:p>","DOI":"10.1002\/jbt.23183","type":"journal-article","created":{"date-parts":[[2022,8,4]],"date-time":"2022-08-04T07:50:02Z","timestamp":1659599402000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Genetic polymorphisms in the mismatch repair pathway (MMR) genes contribute to hematological and gastrointestinal toxicity in North Indian lung cancer patients treated with platinum\u2010based chemotherapy"],"prefix":"10.1002","volume":"36","author":[{"given":"Sidhartha","family":"Singh","sequence":"first","affiliation":[{"name":"Department of Biotechnology Thapar Institute of Engineering &amp; Technology Patiala Punjab India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Navneet","family":"Singh","sequence":"additional","affiliation":[{"name":"Department of Pulmonary Medicine Post Graduate Institute of Medical Education &amp; Research (PGIMER) Chandigarh Punjab India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9414-3771","authenticated-orcid":false,"given":"Siddharth","family":"Sharma","sequence":"additional","affiliation":[{"name":"Department of Biotechnology Thapar Institute of Engineering &amp; Technology Patiala Punjab India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,8,4]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21254"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21208"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.317.7161.771"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.onc.1206933"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1124\/pr.55.1.4"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0215(20000320)89:2<160::AID-IJC10>3.0.CO;2-J"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-04-1953"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcb.24591"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.genet.33.1.533"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2010.05.002"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40880-016-0175-2"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.30921"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/pros.23975"},{"issue":"3","key":"e_1_2_10_15_1","first-page":"271","volume":"17","author":"Khooshemehri P.","year":"2020","journal-title":"Urol. 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