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Curcumin, a polyphenolic compound from the plant turmeric, has been found to possess antiproliferation, anti\u2010inflammation, and antioxidant properties. In this study, the effect of curcumin on Cr (VI)\u2010induced cell survival and migration and the underlying mechanism were investigated. Cell viability assay on A549 and human embryonic lung fibroblast cells\u00a0showed that curcumin at the concentration of 10\u2009\u00b5M could significantly attenuate Cr (VI)\u2010induced viability in both cell lines. Following Western blot assay and metabolomics assays, cotreatment with curcumin and Cr (VI) resulted in the suppression of Cr (VI)\u2010induced glycolysis\u2010, autophagy\u2010, and migration\u2010related proteins. Meanwhile, curcumin increased Cr (VI)\u2010reduced oxidative phosphorylation (OXPHOS)\u2010related proteins, COXIV and ND1. Moreover, curcumin suppressed Cr (VI)\u2010induced mitochondrial dysfunction, mitochondrial mass decrease, and mitochondrial membrane potential loss. Treatment with curcumin for 24\u2009h significantly attenuated pcATG4B\u2010induced autophagy and the subsequent expression of glucose transporter 1, hexokinase II, and pyruvate kinase M2. Wound healing and transwell assay demonstrated that curcumin reduced Cr (VI)\u2010induced cell migration. Taken together, these results showed that curcumin was able to attenuate Cr (VI)\u2010induced cell viability and migration by targeting autophagy\u2010dependent reprogrammed metabolism from OXPHOS to glycolysis.<\/jats:p>","DOI":"10.1002\/jbt.23193","type":"journal-article","created":{"date-parts":[[2022,8,4]],"date-time":"2022-08-04T07:54:09Z","timestamp":1659599649000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Curcumin attenuates Cr (VI)\u2010induced cell growth and migration by targeting autophagy\u2010dependent reprogrammed metabolism"],"prefix":"10.1002","volume":"36","author":[{"given":"Mongameli B.","family":"Dlamini","sequence":"first","affiliation":[{"name":"Department of Occupational and Environmental Health Dalian Medical University Dalian China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shibo","family":"Bao","sequence":"additional","affiliation":[{"name":"Department of Occupational and Environmental Health Dalian Medical University Dalian China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zeyun","family":"Gao","sequence":"additional","affiliation":[{"name":"Department of Occupational and Environmental Health Dalian Medical University Dalian China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Junjie","family":"Mei","sequence":"additional","affiliation":[{"name":"Department of Occupational and Environmental Health Dalian Medical University Dalian China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hong","family":"Ge","sequence":"additional","affiliation":[{"name":"Department of Occupational and Environmental Health Dalian Medical University Dalian China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Liping","family":"Jiang","sequence":"additional","affiliation":[{"name":"Department of Occupational and Environmental Health Dalian Medical University Dalian China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chengyan","family":"Geng","sequence":"additional","affiliation":[{"name":"Department of Occupational and Environmental Health Dalian Medical University Dalian China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qiujuan","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Occupational and Environmental Health Dalian Medical University Dalian China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaoxia","family":"Shi","sequence":"additional","affiliation":[{"name":"Department of Occupational and Environmental Health Dalian Medical University Dalian China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6173-8186","authenticated-orcid":false,"given":"Yong","family":"Liu","sequence":"additional","affiliation":[{"name":"Lab of Pharmacology &amp; Toxicology, School of Life and Pharmaceutical Sciences Dalian University of Technology Panjin China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6894-4011","authenticated-orcid":false,"given":"Jun","family":"Cao","sequence":"additional","affiliation":[{"name":"Department of Occupational and Environmental Health Dalian Medical University Dalian China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2022,8,4]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1177\/2165079918805775"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tox.2014.08.009"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cotox.2017.11.015"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cbi.2008.05.003"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.2147\/OTT.S172909"},{"key":"e_1_2_9_7_1","first-page":"1843","volume":"42","author":"Zhang L.","year":"2019","journal-title":"Oncol. 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