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Fargesin was given 1\u2009h before cadmium treatment for 7 days. Then, the bronchoalveolar lavage fluid (BALF) were harvested to test inflammatory cells and pro\u2010inflammatory cytokine production. Lung histopathological changes, myeloperoxidase (MPO) activity, and aryl hydrocarbon receptor (AhR) and nuclear factor kappa B (NF\u2010\u03baB) activation were measured. Fargesin dose\u2010dependently reduced inflammatory cells and pro\u2010inflammatory cytokines in BALF, improved lung histopathological injury, and inhibited lung wet\/dry ratio and MPO activity. Furthermore, fargesin inhibited cadmium\u2010induced NF\u2010\u03baB activation. In addition, fargesin was found to increase AhR expression. In conclusion, fargesin attenuates cadmium\u2010induced lung injury may be via activating AhR, which subsequently suppressing the inflammatory response.<\/jats:p>","DOI":"10.1002\/jbt.23197","type":"journal-article","created":{"date-parts":[[2022,8,19]],"date-time":"2022-08-19T07:25:07Z","timestamp":1660893907000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Protective effects of fargesin on cadmium\u2010induced lung injury through regulating aryl hydrocarbon receptor"],"prefix":"10.1002","volume":"36","author":[{"given":"Yuting","family":"Zhang","sequence":"first","affiliation":[{"name":"Department of Ophthalmology, Qilu Hospital, Cheeloo College of Medicine Shandong University Jinan China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rui","family":"Ma","sequence":"additional","affiliation":[{"name":"Department of Pharmacy Affiliated Hospital of Shandong University of Traditional Chinese Jinan China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0100-9707","authenticated-orcid":false,"given":"Juan","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology Qilu Hospital of Shandong University Jinan China"},{"name":"NHC Key Laboratory of Otorhinolaryngology Shandong University Jinan China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2022,8,19]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajplung.00107.2012"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00134-012-2682-1"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1155\/2017\/9734837"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/srep12463"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-018-20083-z"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.biochem.71.110601.135414"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1586\/ers.10.71"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1097\/SHK.0b013e31824ddc81"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/jlb.64.1.25"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1097\/TA.0b013e3182127d48"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms18091847"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1038\/aps.2014.112"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.phymed.2016.11.014"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.niox.2008.10.003"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.phymed.2008.04.012"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1139\/cjpp-2015-0615"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.3390\/molecules23061380"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1213\/ANE.0b013e3181baf506"},{"key":"e_1_2_9_20_1","first-page":"2033","volume":"8","author":"Yin N.","year":"2016","journal-title":"Am. 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