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The endometritis model was induced in female BALB\/c mice uterus by perfusion with lipopolysaccharide (LPS) and EGCG were administered at 1\u2009h before LPS induction. The primary bovine endometrial epithelial cells (BEECs) were treated with EGCG for 1\u2009h before LPS stimulation. Uterine histopathological changes, myeloperoxidase (MPO) activity, inflammatory cytokine levels and oxidative stress markers were determined. The extent of Bax, Bcl\u20102, cleaved caspase\u20103, silent information regulator transcript\u20101 (SIRT1), nucleotide oligomerization domain (NOD)\u2010like receptor pyrin domain\u2010containing 3 (NLRP3), apoptosis\u2010associated speck\u2010like protein (ASC) and Caspase1 was detected by Western blot and real\u2010time quantitative PCR assays. The results showed that EGCG significantly reversed the LPS\u2010induced uterine histopathological changes, MPO activity, pro\u2010inflammatory cytokine levels. Additionally, EGCG decreased oxidative stress and reduced cell apoptosis by upregulating SIRT1 expression, downregulating the NLRP3 inflammasome activation. These findings indicated that EGCG exerted its greatest protective effects by blocking inflammatory responses, lowering oxidative stress, and reducing apoptosis via the SIRT1\/NLRP3, making its promising candidate treatment for endometritis.<\/jats:p>","DOI":"10.1002\/jbt.23203","type":"journal-article","created":{"date-parts":[[2022,9,3]],"date-time":"2022-09-03T07:18:13Z","timestamp":1662189493000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["Epigallocatechin\u20103\u2010gallate (EGCG) attenuates inflammatory responses and oxidative stress in lipopolysaccharide (LPS)\u2010induced endometritis via silent information regulator transcript\u20101 (SIRT1)\/nucleotide oligomerization domain (NOD)\u2010like receptor pyrin domain\u2010containing 3 (NLRP3) pathway"],"prefix":"10.1002","volume":"36","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7789-387X","authenticated-orcid":false,"given":"Man","family":"Di","sequence":"first","affiliation":[{"name":"Department of Reproductive Medicine The First Affiliated Hospital of Xi'an Jiaotong University  Xi'an Shaanxi China"},{"name":"Department of Gynecology and Obstetrics, Tangdu Hospital Air Force Medical University  Xi'an Shaanxi China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qianfeng","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Gynecology and Obstetrics Xijing Hospital. 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