{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,10]],"date-time":"2026-07-10T14:38:03Z","timestamp":1783694283880,"version":"3.55.0"},"reference-count":49,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2022,9,18]],"date-time":"2022-09-18T00:00:00Z","timestamp":1663459200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Biochem &amp; Molecular Tox"],"published-print":{"date-parts":[[2022,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Diabetes\u2010related health issues are increasing day by day in public,\u00a0and diabetic cardiomyopathy (DCM) is one serious issue among them. There is a lack of proper strategy to control and manage DCM. Here we are attempting a nutraceutical\u2010based approach to protect the heart from DCM. The beneficial effect of cinnamic acid (CiA), was evaluated in an experimental model of diabetes. For this, diabetic model was created by feeding male Wistar rats with a high fat, high fructose diet for 6 months and a single dose of streptozotocin (25\u2009mg\/kg bwt). Metformin was used as\u00a0the positive control. The diabetic rats showed insulin resistance, myocardial injury, and a significant increase of total cholesterol, triglycerides, and LDL. Development of DCM was evident from the increased cardiac mass index, LDH, CKMB, ANP, and CRP levels in the diabetic group. There was a significant increase in the levels of cardiac hypertrophy markers like TGF\u2010\u03b2 and \u03b2\u2010MHC in the hearts of diabetic rats revealing DCM. Pro\u2010inflammatory cytokines (TNF\u2010\u03b1, IL\u20106) and lipid peroxides were significantly elevated in the serum of diabetic rats. Histopathology revealed inflammation and necrosis in the heart of diabetic rats confirming DCM. Oral administration of CiA (5 and 10\u2009mg\/kg bwt) prevented the development of DCM via its cardioprotective, anti\u2010inflammatory, anti\u2010dyslipidemia potential, and antidiabetic properties. Similarly, metformin (50\u2009mg\/kg bwt) has also shown protection against DCM. We conclude from this study that CiA is found to be beneficial against DCM and recommend more detailed preclinical and clinical studies to develop CiA\u2010based nutraceutical against DCM.<\/jats:p>","DOI":"10.1002\/jbt.23215","type":"journal-article","created":{"date-parts":[[2022,9,19]],"date-time":"2022-09-19T06:30:56Z","timestamp":1663569056000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":35,"title":["Cinnamic acid is beneficial to diabetic cardiomyopathy via its cardioprotective, anti\u2010inflammatory, anti\u2010dyslipidemia, and antidiabetic properties"],"prefix":"10.1002","volume":"36","author":[{"given":"Anupama","family":"Nair","sequence":"first","affiliation":[{"name":"Biochemistry and Molecular Mechanism Laboratory, Division of Agro\u2010Processing and Technology CSIR \u2013 National Institute for Interdisciplinary Science and Technology (NIIST)  Thiruvananthapuram Kerala India"},{"name":"Academy of Scientific and Innovative Research (AcSIR) Council of Scientific and Industrial Research  Ghaziabad India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. R.","family":"Preetha Rani","sequence":"additional","affiliation":[{"name":"Biochemistry and Molecular Mechanism Laboratory, Division of Agro\u2010Processing and Technology CSIR \u2013 National Institute for Interdisciplinary Science and Technology (NIIST)  Thiruvananthapuram Kerala India"},{"name":"Academy of Scientific and Innovative Research (AcSIR) Council of Scientific and Industrial Research  Ghaziabad India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Palayyan","family":"Salin Raj","sequence":"additional","affiliation":[{"name":"Biochemistry and Molecular Mechanism Laboratory, Division of Agro\u2010Processing and Technology CSIR \u2013 National Institute for Interdisciplinary Science and Technology (NIIST)  Thiruvananthapuram Kerala India"},{"name":"Academy of Scientific and Innovative Research (AcSIR) Council of Scientific and Industrial Research  Ghaziabad India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Ranjit","sequence":"additional","affiliation":[{"name":"Jubilee Centre for Medical Research (JCMR) Jubilee Mission Medical College and Research Institute  Thrissur Kerala India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K.","family":"Rajankutty","sequence":"additional","affiliation":[{"name":"Jubilee Centre for Medical Research (JCMR) Jubilee Mission Medical College and Research Institute  Thrissur Kerala India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1341-5470","authenticated-orcid":false,"given":"K. 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