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In this study, we investigated the inhibition effects of 5,7\u2010dichloro\u20108\u2010hydroxyquinoline and methyl 3,4,5\u2010trihydroxybenzoate compounds on the 3\u2010hydroxy\u20103\u2010methylglutaryl coenzyme\u2010A (HMG\u2010CoA Reductase) and urease enzymes. We have obtained results for the HMG\u2010CoA Reductase and urease enzymes at the micromolar level. In our study, inhibition result of 5,7\u2010dichloro\u20108\u2010hydroxyquinoline and Methyl 3,4,5\u2010trihydroxybenzoate on HMG\u2010CoA reductase showed lower values 2.28\u2009\u00b1\u20090.78 and 33.25\u2009\u00b1\u20095.04\u2009\u00b5g\/ml, respectively. Additionally, inhibition result of 5,7\u2010dichloro\u20108\u2010hydroxyquinoline and methyl 3,4,5\u2010trihydroxybenzoate on urease showed lower values 6.18\u2009\u00b1\u20091.38 and 8.51\u2009\u00b1\u20091.35\u2009\u00b5g\/ml, respectively. Molecular docking calculations were made for their biological activities were compared. In the present work, the structures of the related compounds (<jats:bold>1 and 2<\/jats:bold>) were drawn using Gaussian 09 software and done geometry optimization at DFT\/B3LYP\/6\u201031G* basis set with aforementioned program. Cytotoxicity potential of these compounds against human lung cancer demonstrated that these compounds had good cytotoxic effects. Both compounds significantly decreased lung cell viability from low doses. In addition, 100\u2009\u00b5M dose of all compounds caused significant reductions in lung cell viability. In general, we can say that of the two tested compounds, 5,7\u2010dichloro\u20108\u2010hydroxyquinoline and methyl 3,4,5\u2010trihydroxybenzoate have cytotoxic effects in all cell types, and this effect is particularly strong in lung cells. Activities were performed at concentrations of 10, 20, 50, 70, and 100\u2009\u00b5l and we achieved good results. Lung cell viability (%) value was better at 100\u2009\u00b5l concentration and IC<jats:sub>50<\/jats:sub> of them were 54.28 and 48.05\u2009\u00b5M.<\/jats:p>","DOI":"10.1002\/jbt.23222","type":"journal-article","created":{"date-parts":[[2022,9,15]],"date-time":"2022-09-15T02:54:25Z","timestamp":1663210465000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Therapeutic properties\u00a0and molecular docking study of some phenolic compounds as anti\u2010human lung cancer potential: A biochemical approach"],"prefix":"10.1002","volume":"37","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8097-6879","authenticated-orcid":false,"given":"Hongqing","family":"Wen","sequence":"first","affiliation":[{"name":"Pulmonary and Critical Care Medicine Northwest University Affiliated Hospital\/Xi'an No.3 Hospital Xi'an Shaanxi China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2422-4653","authenticated-orcid":false,"given":"Lei","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Respiratory and Critical Care Medicine Tianjin Chest Hospital Tianjin City China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kareem","family":"Morsy","sequence":"additional","affiliation":[{"name":"Department of Biology, College of Science King Khalid University Abha Saudi Arabia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hamida","family":"Hamdi","sequence":"additional","affiliation":[{"name":"Department of Biology, Faculty of Science Taif University Taif Saudi Arabia"},{"name":"Department of Zoology, Faculty of Science Cairo University Cairo Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ayman E.","family":"El\u2010Kenawy","sequence":"additional","affiliation":[{"name":"Department of Pathology, College of Medicine Taif University Taif Saudi Arabia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5060-0790","authenticated-orcid":false,"given":"Attalla F.","family":"El\u2010kott","sequence":"additional","affiliation":[{"name":"Department of Biology, College of Science King Khalid University Abha Saudi Arabia"},{"name":"Department of Zoology, Faculty of Science Damanhour University Damanhour Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2022,9,14]]},"reference":[{"key":"e_1_2_8_2_1","first-page":"49","volume":"63","author":"De C. 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