{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,24]],"date-time":"2026-06-24T17:07:17Z","timestamp":1782320837094,"version":"3.54.5"},"reference-count":25,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2022,9,26]],"date-time":"2022-09-26T00:00:00Z","timestamp":1664150400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Biochem &amp;amp; Molecular Tox"],"published-print":{"date-parts":[[2023,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Corynoline has been reported to have anti\u2010inflammatory and antioxidative effects. In the present study, the potential protective effects of corynoline against zearalenone (ZEA)\u2010induced liver injury were investigated. ZEA was administered daily for 5 days. Then, liver tissues were used for subsequent experiments. Corynoline attenuated liver histopathological changes induced by ZEA. The production of tumor necrosis factor\u2010\u03b1 and interleukin\u20101\u03b2 in liver tissues, as well as aspartate aminotransferase and alanine aminotransferase in serum, was also inhibited by corynoline. Meanwhile, ZEA\u2010induced MPO activity and MDA content were both attenuated by corynoline. ZEA\u2010induced NF\u2010\u03baB p65 and I\u03baB\u03b1 phosphorylation were inhibited by corynoline. Furthermore, SIRT1, Nrf2, and HO\u20101 expression were increased by corynoline. In addition, the protective effects of corynoline against liver injury were reversed by the SIRT1 inhibitor EX\u2010527. Taken together, corynoline protected against ZEA\u2010induced liver injury by activating the SIRT1\/Nrf2 signaling pathway.<\/jats:p>","DOI":"10.1002\/jbt.23224","type":"journal-article","created":{"date-parts":[[2022,9,26]],"date-time":"2022-09-26T05:39:10Z","timestamp":1664170750000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Corynoline protects against zearalenone\u2010induced liver injury by activating the SIRT1\/Nrf2 signaling pathway"],"prefix":"10.1002","volume":"37","author":[{"given":"Liqun","family":"Sun","sequence":"first","affiliation":[{"name":"Department of Pathogenobiology, Jilin University Mycology Research Center, College of Basic Medical Sciences Jilin University  Changchun Jilin Province China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dan","family":"He","sequence":"additional","affiliation":[{"name":"Department of Pathogenobiology, Jilin University Mycology Research Center, College of Basic Medical Sciences Jilin University  Changchun Jilin Province China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuhuan","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Pathogenobiology, Jilin University Mycology Research Center, College of Basic Medical Sciences Jilin University  Changchun Jilin Province China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yunyun","family":"Wei","sequence":"additional","affiliation":[{"name":"Department of Pathogenobiology, Jilin University Mycology Research Center, College of Basic Medical Sciences Jilin University  Changchun Jilin Province China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5302-2527","authenticated-orcid":false,"given":"Li","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Pathogenobiology, Jilin University Mycology Research Center, College of Basic Medical Sciences Jilin University  Changchun Jilin Province China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,9,26]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1053\/jhep.2001.23505"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.gastro.2005.05.006"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.intimp.2014.02.012"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2613.2000.00144.x"},{"key":"e_1_2_8_6_1","first-page":"957","volume":"10","author":"Li L.","year":"2018","journal-title":"Am. 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