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Further, we revealed the effects and mechanisms of miRNA\u20109a\u20105p for regulating\u00a0IBD progression. In C57BL\/6N mice, IBD was induced with dextran sodium sulfate (DSS), and the effects of endogenous miRNA\u20109a\u20105p were mimicked\/antagonized through intraperitoneal injection of miRNA\u20109a\u20105p agomir and antagomir. In animal experimentation, agomir could inhibit intestinal inflammation and tissue damage, and reduce the mucosal barrier permeability. Antagomir, on the other hand, could promote barrier damage, whose effect was associated with the M1 macrophage polarization.\u00a0This study finds that miRNA\u20109a\u20105p targets NOX4 to suppress\u00a0ROS production, which plays an important role in mucosal barrier damage in IBD.<\/jats:p>","DOI":"10.1002\/jbt.23245","type":"journal-article","created":{"date-parts":[[2022,10,25]],"date-time":"2022-10-25T06:09:06Z","timestamp":1666678146000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["MicroRNA\u20109a\u20105p\u2010NOX4 inhibits intestinal inflammatory injury by regulating the M1 polarization of intestinal macrophages"],"prefix":"10.1002","volume":"37","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6109-116X","authenticated-orcid":false,"given":"Wenyan","family":"Li","sequence":"first","affiliation":[{"name":"Department of Pharmacy The Second Affiliated Hospital of Jiaxing University Jiaxing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yongjia","family":"Sheng","sequence":"additional","affiliation":[{"name":"Department of Pharmacy The Second Affiliated Hospital of Jiaxing University Jiaxing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jin","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Pharmacy The Second Affiliated Hospital of Jiaxing University Jiaxing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8819-4246","authenticated-orcid":false,"given":"Shasha","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Pharmacy The Second Affiliated Hospital of Jiaxing University Jiaxing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2805-580X","authenticated-orcid":false,"given":"Chenyang","family":"Han","sequence":"additional","affiliation":[{"name":"Department of Pharmacy The Second Affiliated Hospital of Jiaxing University Jiaxing China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,10,24]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/biof.1375"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1097\/EJA.0000000000000593"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/imm.12741"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.intimp.2017.01.032"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.intimp.2021.108361"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1248\/bpb.b17-00362"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1097\/MIB.0000000000001059"},{"issue":"4","key":"e_1_2_9_9_1","first-page":"285","volume":"4","author":"Fern\u00e1ndez\u2010Tom\u00e9 S.","year":"2019","journal-title":"Trends Food Sci. 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