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Enzyme inhibition is a very active area of research in drug design and development. In this study, the synthesized novel benzimidazolium salts were evaluated toward the human erythrocyte carbonic anhydrase I (hCA I), and II (hCA II) isoenzymes, acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) enzymes. They demonstrated highly potent inhibition ability against hCA I with K<jats:sub>i<\/jats:sub> values of 484.8\u2009\u00b1\u200962.6\u20131389.7\u2009\u00b1\u2009243.2\u2009nM, hCA II with K<jats:sub>i<\/jats:sub> values of 298.9\u2009\u00b1\u200955.7\u2013926.1\u2009\u00b1\u2009330.0\u2009nM, \u03b1\u2010glycosidase with K<jats:sub>i<\/jats:sub> values of 170.3\u2009\u00b1\u200927\u2013760.1\u2009\u00b1\u2009269\u2009\u03bcM, AChE with K<jats:sub>i<\/jats:sub> values of 27.1\u2009\u00b1\u20093\u201377.6\u2009\u00b1\u20091.7\u2009nM,\u00a0and BChE with K<jats:sub>i<\/jats:sub> values of 21.0\u2009\u00b1\u20095\u201361.3\u2009\u00b1\u200915\u2009nM. As a result, novel vinyl functionalized 5,6\u2010dimethylbenzimidazolium salts (<jats:italic>1a\u2013g<\/jats:italic>) exhibited effective inhibition profiles toward studied metabolic enzymes. Therefore, we believe that these results may contribute to the development of new drugs particularly to treat some global disorders including glaucoma, Alzheimer's disease, and diabetes.<\/jats:p>","DOI":"10.1002\/jbt.23255","type":"journal-article","created":{"date-parts":[[2022,11,25]],"date-time":"2022-11-25T03:40:47Z","timestamp":1669347647000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Vinyl functionalized 5,6\u2010dimethylbenzimidazolium salts: Synthesis and biological activities"],"prefix":"10.1002","volume":"37","author":[{"given":"Emine \u00d6.","family":"Karaca","sequence":"first","affiliation":[{"name":"Catalysis Research and Application Center \u0130n\u00f6n\u00fc University Malatya Turkey"},{"name":"Drug Application and Research Center \u0130n\u00f6n\u00fc University Malatya Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zeynebe","family":"Bing\u00f6l","sequence":"additional","affiliation":[{"name":"Tokat Vocational School of Health Services, Department of Medical Services and Techniques Gaziosmanpasa University Tokat Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nevin","family":"G\u00fcrb\u00fcz","sequence":"additional","affiliation":[{"name":"Catalysis Research and Application Center \u0130n\u00f6n\u00fc University Malatya Turkey"},{"name":"Drug Application and Research Center \u0130n\u00f6n\u00fc University Malatya Turkey"},{"name":"Department of Chemistry, Faculty of Science and Art \u0130n\u00f6n\u00fc University Malatya Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6325-0216","authenticated-orcid":false,"given":"\u0130smail","family":"\u00d6zdemir","sequence":"additional","affiliation":[{"name":"Catalysis Research and Application Center \u0130n\u00f6n\u00fc University Malatya Turkey"},{"name":"Drug Application and Research Center \u0130n\u00f6n\u00fc University Malatya Turkey"},{"name":"Department of Chemistry, Faculty of Science and Art \u0130n\u00f6n\u00fc University Malatya Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5993-1668","authenticated-orcid":false,"given":"\u0130lhami","family":"G\u00fcl\u00e7in","sequence":"additional","affiliation":[{"name":"Department of Chemistry, Faculty of Sciences Ataturk University Erzurum Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2022,11,24]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.3906\/kim-1510-31"},{"key":"e_1_2_8_2_2","doi-asserted-by":"publisher","DOI":"10.24820\/ark.5550190.p010.519"},{"key":"e_1_2_8_2_3","doi-asserted-by":"publisher","DOI":"10.1016\/j.molstruc.2021.130204"},{"key":"e_1_2_8_2_4","doi-asserted-by":"publisher","DOI":"10.1016\/j.molstruc.2021.130883"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1021\/ja710276x"},{"key":"e_1_2_8_3_2","doi-asserted-by":"publisher","DOI":"10.1002\/aoc.1392"},{"key":"e_1_2_8_3_3","doi-asserted-by":"publisher","DOI":"10.1016\/j.poly.2021.115091"},{"key":"e_1_2_8_3_4","doi-asserted-by":"publisher","DOI":"10.1039\/D1NJ04606C"},{"key":"e_1_2_8_4_1","first-page":"699","volume":"35","author":"\u00d6zcan E. \u00d6.","year":"2011","journal-title":"Turk. 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