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The animals were divided into seven groups: control (Group I) and Group II were treated with 50% ethanol (EtOH 5\u2009mg\/kg). Groups III, IV, and VI were treated with (EtOH + CB 10\u2009mg\/kg), (EtOH + CB 20\u2009mg\/kg), and (EtOH + CB 30\u2009mg\/kg), respectively. Groups V and VII consisted of animals treated with 20 and 30\u2009mg\/kg, of CB, respectively. Biochemical analysis revealed that Group IV (EtOH + CB 20\u2009mg\/kg) had reduced levels of ALT\u2014alanine transferase, AST\u2014aspartate aminotransferase, ALP\u2014alanine peroxidase, MDA\u2014malondialdehyde and increased levels of GSH\u2010reduced glutathione. Histopathological analysis of liver and kidney tissues showed that EtOH + CB (20 and 30\u2009mg\/kg) treated animal groups exhibited normal tissue architecture similar to that of the control group. ELISA revealed that the inflammatory markers were reduced in the animal groups that were treated with EtOH + CB 20\u2009mg\/kg, in comparison to the animals treated only with EtOH. The mRNA expression levels of COX\u20102, CD\u201014, and MIP\u20102 showed a remarkable decrease in EtOH + CB treated animal groups to control groups. Western blot analysis revealed that CB downregulated p38\/JNK\/ERK thereby exhibiting its hepatoprotective property by inhibiting mitogen\u2010activated protein kinase\u00a0pathways. Thus, our findings suggest that CB is a potential candidate for the treatment of alcohol\u2010induced hepatotoxicity.<\/jats:p>","DOI":"10.1002\/jbt.23260","type":"journal-article","created":{"date-parts":[[2022,12,1]],"date-time":"2022-12-01T13:47:12Z","timestamp":1669902432000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Cannabinoids inhibit ethanol\u2010induced activation of liver toxicity in rats through JNK\/ERK\/MAPK signaling pathways"],"prefix":"10.1002","volume":"37","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9996-0295","authenticated-orcid":false,"given":"Lei","family":"Yan","sequence":"first","affiliation":[{"name":"Clinical Experimental Centre Xi'an International Medical Center Hospital Xi'an Shaanxi Province China"},{"name":"M.Kandiah Faculty of Medicine and Health Sciences Universiti Tunku Abdul Rahman Bandar Sungai Long Selangor Malaysia"},{"name":"Xi'an Engineering Technology Research Center for Cardiovascular Active Peptide  Xi'an Shaanxi Province China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Heng","family":"Luo","sequence":"additional","affiliation":[{"name":"Reproductive Medicine Center, Tangdu Hospital Fourth Military Medical University  Xi'an Shaanxi Province China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaolu","family":"Tang","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery The Second Affiliated Hospital of Xi'an Medical University  Xi'an Shaanxi Province China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2636-3411","authenticated-orcid":false,"given":"Haidong","family":"Wang","sequence":"additional","affiliation":[{"name":"Inpatient Clinical Laboratory Department The Second Affiliated Hospital of Xi'an Medical University  Xi'an Shaanxi Province China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2022,12]]},"reference":[{"key":"e_1_2_9_2_1","first-page":"18","volume":"82","author":"Badawi M. 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