{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T16:09:04Z","timestamp":1791216544215,"version":"4.1.0"},"reference-count":54,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2022,12,11]],"date-time":"2022-12-11T00:00:00Z","timestamp":1670716800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Biochem & Molecular Tox"],"published-print":{"date-parts":[[2023,3]]},"abstract":"Abstract<\/jats:title>ATP\u2010binding cassette (ABC) transporters are expressed in various human tissues and play a vital role in the efflux of various chemotherapeutic drugs. The current study has assessed genetic variants of ABCB1, ABCC1, ABCC2<\/jats:italic>, and ABCG2<\/jats:italic> genes in 407 lung cancer patients undergoing platinum\u2010based doublet chemotherapy. The association of ABCB1<\/jats:italic>\u00a0(C<\/jats:italic>1236<\/jats:italic><\/jats:sup>T<\/jats:italic>, C<\/jats:italic>3435<\/jats:italic><\/jats:sup>T<\/jats:italic>, and G<\/jats:italic>2677<\/jats:italic><\/jats:sup>T\/A<\/jats:italic>), ABCC1<\/jats:italic>\u00a0(G<\/jats:italic>3173<\/jats:italic><\/jats:sup>A<\/jats:italic> and G<\/jats:italic>2168<\/jats:italic><\/jats:sup>A<\/jats:italic>),ABCC2<\/jats:italic> (G<\/jats:italic>4544<\/jats:italic><\/jats:sup>A<\/jats:italic>), and ABCG2<\/jats:italic>\u00a0(C<\/jats:italic>421<\/jats:italic><\/jats:sup>A<\/jats:italic>) polymorphisms with chemotherapy\u2010induced adverse events were assessed, and statistical analysis was conducted. Our data showed that patients harboring heterozygous (GA<\/jats:italic>) genotype for ABCC1 G<\/jats:italic>3173<\/jats:italic><\/jats:sup>A<\/jats:italic> had an increased risk of developing leukopenia (odds ratio [OR]\u2009=\u20091.88, p<\/jats:italic>\u2009=\u20090.04) and anemia (adjusted odds ratio\u00a0[AOR]\u2009=\u20092.70, p<\/jats:italic>\u2009=\u20090.03). For ABCC2 G<\/jats:italic>4544<\/jats:italic><\/jats:sup>A<\/jats:italic> polymorphism, patients harboring one copy of the mutant (GA<\/jats:italic>) allele showed an increased risk of developing anemia (OR\u2009=\u20094.24, p<\/jats:italic>\u2009=\u20090.03). After adjusting with various confounding factors, the heterozygous (GA<\/jats:italic>) genotype showed a 5.63\u2010fold increased risk of developing anemia (AOR\u2009=\u20095.63, p<\/jats:italic>\u2009=\u20090.03). The ABCB1 G<\/jats:italic>2677<\/jats:italic><\/jats:sup>A<\/jats:italic> (OR\u2009=\u20090.37, p<\/jats:italic>\u2009=\u20090.008) and ABCC1 G<\/jats:italic>3173<\/jats:italic><\/jats:sup>A<\/jats:italic> (OR\u2009=\u20090.54, p<\/jats:italic>\u2009=\u20090.04) polymorphism showed a lower incidence of developing nephrotoxicity. In ABCG2 C<\/jats:italic>421<\/jats:italic><\/jats:sup>A<\/jats:italic> polymorphism, patients harboring heterozygous (CA<\/jats:italic>) genotype had a lower incidence of having diarrhea (OR\u2009=\u20090.25, p<\/jats:italic>\u2009=\u20090.04). An increased risk of having diarrhea was observed in the heterozygous genotype (GA<\/jats:italic>) for ABCC1 G<\/jats:italic>3173<\/jats:italic><\/jats:sup>A<\/jats:italic> polymorphism (AOR\u2009=\u20092.78, p<\/jats:italic>\u2009=\u20090.04). An increased risk of liver injury was found in the patients carrying heterozygous genotype of the ABCC1 G<\/jats:italic>3173<\/jats:italic><\/jats:sup>A<\/jats:italic> (OR\u2009=\u20092.06, p<\/jats:italic>\u2009=\u20090.02) and ABCB1 C<\/jats:italic>1236<\/jats:italic><\/jats:sup>T<\/jats:italic> (OR\u2009=\u20091.85, p<\/jats:italic>\u2009=\u20090.01). This study demonstrates the role of polymorphic variations in ABCB1, ABCC1, ABCC2<\/jats:italic>, and ABCG2<\/jats:italic> in predicting hematological, nephrotoxicity, gastrointestinal, and hepatotoxicity.<\/jats:p>","DOI":"10.1002\/jbt.23269","type":"journal-article","created":{"date-parts":[[2022,12,12]],"date-time":"2022-12-12T07:34:20Z","timestamp":1670830460000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Genetic variations in ABC<\/i> transporter genes as a predictive biomarker for toxicity in North Indian lung cancer patients undergoing platinum\u2010based doublet chemotherapy"],"prefix":"10.1002","volume":"37","author":[{"given":"Parul","family":"Sharma","sequence":"first","affiliation":[{"name":"Department of Biotechnology Thapar Institute of Engineering & Technology Patiala Punjab India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Navneet","family":"Singh","sequence":"additional","affiliation":[{"name":"Department of Pulmonary Medicine Post Graduate Institute of Medical Education & Research Chandigarh India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9414-3771","authenticated-orcid":false,"given":"Siddharth","family":"Sharma","sequence":"additional","affiliation":[{"name":"Department of Biotechnology Thapar Institute of Engineering & Technology Patiala Punjab India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,12,11]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21551"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra0802714"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2019.01573"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdw326"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/1759-7714.12168"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1038\/srep11556"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12032-017-0905-6"},{"issue":"3","key":"e_1_2_11_9_1","first-page":"201","volume":"1","author":"Hampras S. 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