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The toxicity of As is known to affect the liver, kidney, lungs, muscles, cardiovascular system, and nervous system and can even induce diabetes. Further As can cause skin lesions leading to notable diseases in the skin like Bowen's disease. Chronic exposure to As has caused many tragedies in Eastern, and several Southeast Asian and Latin American countries. Long\u2010term exposure to As makes it an immediate threat that should be dealt with as a priority, and one of the ways to handle it may be with the use of antioxidants. In this review, we have discussed the natural and anthropogenic sources of As, its metabolism, pathophysiology, and mechanism of toxicity. Besides, we have also discussed some of the synthetic chelators and the ameliorative role of antioxidants and natural compounds in reducing As toxicity.<\/jats:p>","DOI":"10.1002\/jbt.23281","type":"journal-article","created":{"date-parts":[[2022,12,23]],"date-time":"2022-12-23T05:40:33Z","timestamp":1671774033000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":24,"title":["Arsenic\u2010induced toxicity and the ameliorative role of antioxidants and natural compounds"],"prefix":"10.1002","volume":"37","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5500-8534","authenticated-orcid":false,"given":"Sadiya S.","family":"Shiek","sequence":"first","affiliation":[{"name":"Department of Biology College of Science, United Arab Emirates University  United Arab Emirates"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2480-5842","authenticated-orcid":false,"given":"Sanai T.","family":"Sajai","sequence":"additional","affiliation":[{"name":"Manipal School of Life Sciences Manipal Academy of Higher Education (MAHE) Manipal Karnataka India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6747-9595","authenticated-orcid":false,"given":"Herman S.","family":"Dsouza","sequence":"additional","affiliation":[{"name":"Department of Radiation Biology and Toxicology Manipal School of Life Sciences, Manipal Academy of Higher Education (MAHE) Manipal Karnataka India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,12,22]]},"reference":[{"key":"e_1_2_15_2_1","doi-asserted-by":"publisher","DOI":"10.3961\/jpmph.14.036"},{"key":"e_1_2_15_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0378-4274(01)00534-3"},{"key":"e_1_2_15_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/S10534-022-00371-Y"},{"key":"e_1_2_15_5_1","doi-asserted-by":"publisher","DOI":"10.1001\/JAMAONCOL.2021.5206"},{"key":"e_1_2_15_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.scitotenv.2013.10.039"},{"key":"e_1_2_15_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/J.SCITOTENV.2011.08.051"},{"key":"e_1_2_15_8_1","doi-asserted-by":"publisher","DOI":"10.1136\/pmj.79.933.391"},{"key":"e_1_2_15_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/J.ENVINT.2008.07.023"},{"key":"e_1_2_15_10_1","doi-asserted-by":"publisher","DOI":"10.4103\/0971-6580.84258"},{"issue":"2","key":"e_1_2_15_11_1","first-page":"359","volume":"28","author":"Singh N.","year":"2007","journal-title":"J. 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