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Upregulation of circ\u2010ERBB2 promoted CRC cells proliferation and clone formation, but inhibited apoptosis. We identified miR\u2010181a\u20105p as circ\u2010ERBB2's target. The effect of miR\u2010181a\u20105p on CRC cells was contrary to circ\u2010ERBB2, miR\u2010181a\u20105p downregulation abolished the function of circ\u2010ERBB2 silencing in CRC cells. In addition, phosphatase and tensin homolog (PTEN) was verified as miR\u2010181a\u20105p's downstream target, circ\u2010ERBB2 activates the Akt pathway and inhibits cell apoptosis through modulating miR\u2010181a\u20105p\/PTEN. Circ\u2010ERBB2 silencing significantly reduced CRC cell resistance to 5\u2010FU. miR\u2010181a\u20105p downregulation abolished the role of circ\u2010ERBB2 knockdown in CRC cell resistance to 5\u2010FU. In conclusion, upregulation of circ\u2010ERBB2 promoted the malignancy of CRC and reduced CRC cell resistance to 5\u2010FU. Besides, additional mechanism study provided a novel regulatory pathways that circ\u2010ERBB2 knockdown promoted CRC cell sensitivity to 5\u2010FU by regulating miR\u2010181a\u20105p\/PTEN\/Akt pathway. This research indicated that circ\u2010ERBB2 may be a valuable biomarker for the diagnosis and treatment of CRC.<\/jats:p>","DOI":"10.1002\/jbt.23297","type":"journal-article","created":{"date-parts":[[2023,1,14]],"date-time":"2023-01-14T06:25:51Z","timestamp":1673677551000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Circ\u2010ERBB2 knockdown sensitized colorectal cancer cells to 5\u2010FU via miR\u2010181a\u20105p\/PTEN\/Akt pathway"],"prefix":"10.1002","volume":"37","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2309-8632","authenticated-orcid":false,"given":"Yueli","family":"Zhang","sequence":"first","affiliation":[{"name":"Department of Clinical Pharmacy Zhengzhou Central Hospital Affiliated to Zhengzhou University  Zhengzhou People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinchun","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of 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