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This disorder is poorly understood, particularly the effect of acetaldehyde, the primary alcohol metabolite, in the endocrine pancreas. Hepatocyte growth factor (HGF) is a protective protein in many tissues, displaying antioxidant, antiapoptotic, and proliferative responses. In the present work, we were focused on characterizing the response induced by HGF and its protective mechanism in the RINm5F pancreatic cell line treated with ethanol and acetaldehyde. RINm5F cells were treated with ethanol or acetaldehyde for 12\u2009h in the presence or not of HGF (50\u2009ng\/ml). Cells under HGF treatment decreased the content of reactive oxygen species and lipid peroxidation induced by both toxics, improving cell viability. This effect was correlated to an improvement in insulin expression impaired by ethanol and acetaldehyde. Using a specific inhibitor of Erk1\/2 abrogated the effects elicited by the growth factor. In conclusion, the work provides mechanistic evidence of the HGF\u2010induced\u2010protective response to the alcohol\u2010induced damage in the main cellular component of the endocrine pancreas.<\/jats:p>","DOI":"10.1002\/jbt.23302","type":"journal-article","created":{"date-parts":[[2023,1,13]],"date-time":"2023-01-13T07:34:05Z","timestamp":1673595245000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Erk1\/2 signaling mediates the HGF\u2010induced protection against ethanol and acetaldehyde\u2010induced toxicity in the pancreatic RINm5F cell line"],"prefix":"10.1002","volume":"37","author":[{"given":"Mayrel","family":"Palestino\u2010Dom\u00ednguez","sequence":"first","affiliation":[{"name":"Posgrado en Biolog\u00eda Experimental, DCBS Universidad Aut\u00f3noma Metropolitana Iztapalapa  Mexico City Mexico"},{"name":"Area de Medicina Experimental y Traslacional, Departamento de Ciencias de la Salud Universidad 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