{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,22]],"date-time":"2026-04-22T16:49:11Z","timestamp":1776876551637,"version":"3.51.2"},"reference-count":47,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2023,1,13]],"date-time":"2023-01-13T00:00:00Z","timestamp":1673568000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Biochem &amp;amp; Molecular Tox"],"published-print":{"date-parts":[[2023,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The release of inflammatory cytokines, namely tumor necrosis factor\u2010\u03b1 (TNF\u2010\u03b1), plays an important role in the pathogenesis of cardiomyopathy. TNF\u2010\u03b1 increases in plasma and in myocardium of heart failure patients. We aimed to investigate the role of TNF\u2010\u03b1 inhibitor (infliximab; IFX) in regulating dilated cardiomyopathy (DCM) induced in rats. DCM was induced in rats by doxorubicin (DOX; 3.5\u2009mg. kg<jats:sup>\u22121<\/jats:sup>, i.p) twice weekly for 3 weeks (21\u2009mg. kg<jats:sup>\u22121<\/jats:sup> cumulative dose). DCM rats were treated with RPL (1\u2009mg. kg<jats:sup>\u22121<\/jats:sup> orally, daily), IFX (5\u2009mg. kg<jats:sup>\u22121<\/jats:sup>; i.p. once) or their combination for 4 weeks starting next day of last DOX dose. Echocardiography was conducted followed by a collection of blood and left ventricle (LV) for biochemical and histological investigations. DCM rats revealed deteriorated cardiac function (increased CK\u2010MB activity, LVIDs, LVIDd, ESV, and EDV, while decreased EF% and FS%), hypertrophy (increased HW\/TL, \u03b2\u2010MHC, and \u03b1\u2010actin), inflammation (increased IL\u20101\u03b2, IL\u20106, and TNF\u2010\u03b1). The activation of Wnt\/\u03b2\u2010catenin along with increased gene expression of RAS components (RENIN, ACE, and AT1) were evident. LV architecture also revealed abnormalities and some degree of fibrosis. Treatment with RPL and\/or IFX suppressed TNF\u2010\u03b1 and consequently improved most of these parameters suppressing Wnt\/\u03b2\u2010catenin\/RAS axis. Combined RPL and IFX treatment was the best among all treatments. In conclusion, Wnt\/\u03b2\u2010catenin\/RAS axis is implicated in DOX\u2010induced cardiomyopathy. The upstream TNF\u2010\u03b1 was proved for the first time in\u2010vivo to stimulate this axis where its inhibition by RPL or IFX prevented DCM. Targeting this axis at two points using RPL and IFX showed better therapeutic efficacy.<\/jats:p>","DOI":"10.1002\/jbt.23312","type":"journal-article","created":{"date-parts":[[2023,1,13]],"date-time":"2023-01-13T14:26:26Z","timestamp":1673619986000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["RETRACTED: Infliximab substantially re\u2010silenced Wnt\/\u03b2\u2010catenin signaling and ameliorated doxorubicin\u2010induced cardiomyopathy in rats"],"prefix":"10.1002","volume":"37","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2593-2459","authenticated-orcid":false,"given":"Hoda E.","family":"Mohamed","sequence":"first","affiliation":[{"name":"Department of Biochemistry, Faculty of Pharmacy Zagazig University  Zagazig Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mervat E.","family":"Askar","sequence":"additional","affiliation":[{"name":"Department of Biochemistry, Faculty of Pharmacy Zagazig University  Zagazig Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mohamed A.","family":"Shaheen","sequence":"additional","affiliation":[{"name":"Department of Histology and Cell Biology, Faculty of Human Medicine Zagazig University  Zagazig Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alaa E.","family":"Salama","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Faculty of Human Medicine Zagazig University  Zagazig Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Reham A.","family":"Idris","sequence":"additional","affiliation":[{"name":"Department of Biochemistry, Faculty of Pharmacy Zagazig University  Zagazig Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4747-7095","authenticated-orcid":false,"given":"Nahla N.","family":"Younis","sequence":"additional","affiliation":[{"name":"Department of Biochemistry, Faculty of Pharmacy Zagazig University  Zagazig Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2023,1,13]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2016.03.590"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2407-10-337"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00059-011-3470-3"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0119214"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1089\/ars.2012.4795"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1159\/000338166"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2017.05.016"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1038\/labinvest.2015.153"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13619-015-0017-8"},{"key":"e_1_2_7_11_1","volume":"26","author":"Zhao Z.","year":"2020","journal-title":"Med. 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