{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,10]],"date-time":"2026-05-10T17:26:48Z","timestamp":1778434008633,"version":"3.51.4"},"reference-count":31,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2023,1,17]],"date-time":"2023-01-17T00:00:00Z","timestamp":1673913600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Biochem &amp;amp; Molecular Tox"],"published-print":{"date-parts":[[2023,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The pesticide malathion (MT), an organophosphate, is highly neurotoxic and causes cholinergic disorders as well as cytotoxicity, genotoxicity, mutagenicity, carcinogenicity\u00a0and reproductive toxicity. Our purpose was to study the effect of ellagic acid (EA)\u00a0and Vitamin C on the testis against MT\u2010induced toxicity in the rats. Thirty\u2010six adult Wistar rats were employed, separated into six groups\u00a0and were given treatment for 14 days. The toxicity of MT on the testis was evaluated using a variety of physical parameters,\u00a0such as mortality rate and body weight, as well as biochemical parameters, such as total protein, total cholesterol, serum glutamic\u2010oxaloacetic transaminase\u00a0and serum glutamic\u2010pyruvic transaminase, and haematological parameters, such as counts of red blood cells, haemoglobin (Hb)\u00a0and white blood cells, as well as mean corpuscular volume, mean corpuscular Hb, and mean corpuscular Hb\u00a0concentration. At the end of the experiment, rats were killed and a histological examination of the testis was performed. A sperm count technique and an analysis of sperm motility were used to determine the sperm quality. Biochemical indicators, sperm count, motility, viability\u00a0and morphology were significantly decreased with MT. When compared with\u00a0MT and the control group, EA and Vitamin C administration significantly increased sperm motility and count (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.05). After receiving EA and Vitamin C, biochemical indicators and histological characteristics are also intensified. The results of the current investigation show\u00a0that EA and Vitamin C can both reduce increased levels of biochemical markers and improve pathological alterations in the testis brought on by MT treatment.<\/jats:p>","DOI":"10.1002\/jbt.23314","type":"journal-article","created":{"date-parts":[[2023,1,18]],"date-time":"2023-01-18T06:31:38Z","timestamp":1674023498000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Ameliorative effect of ellagic acid and Vitamin C against malathion\u2010induced toxicity in testis of adult Wistar rats"],"prefix":"10.1002","volume":"37","author":[{"given":"Rahul","family":"Gupta","sequence":"first","affiliation":[{"name":"Department of Pharmacology Delhi Pharmaceutical Sciences &amp; Research University (DPSRU)  New Delhi India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8254-0400","authenticated-orcid":false,"given":"Tinku","family":"Gupta","sequence":"additional","affiliation":[{"name":"SRM Modinagar College of Pharmacy, SRMIST SRM University  Ghaziabad India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dhirender","family":"Kaushik","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Sciences Gurugram University  Gurugram India"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2023,1,17]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.atg.2015.07.001"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.etp.2011.03.002"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1186\/s41935-018-0099-x"},{"issue":"2","key":"e_1_2_9_5_1","first-page":"262","volume":"11","author":"Ahmed T. 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