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The results indicated that DOX impaired hepatic function, as measured by an increased levels of liver weight index and serum concentrations of aspartate transaminase and alanine transaminase, as well as alteration of hepatic histology. In addition, DOX increased the serum levles of triglyceride\u00a0(TG) and nonestesterified fatty acid. ATO prevented these changes. Mechanical analysis revealed that ATO restored the changes of malondialdehyde, reactive oxygen radical species, glutathione peroxidase and manganese superoxide dismutase. Additionally, ATO inhibited the increased expression levels of nuclear factor\u2010kappa B and interleukin 1\u03b2, hence suppressing inflammation. Meanwhile, ATO inhibited cell apoptosis by dramatically decreasing the Bax\/Bcl\u20102 ratio. In addition, ATO mitigated the lipidtoxicity by inhibiting the adipolysis of TG and accelerating hepatic lipid metabolism. Taken together, the results suggest ATO has therapeutic effect on DOX\u2010induced hepatotoxicity via inhibition of oxidative damage, inflammatory and apoptosis. In addition, ATO attenuates DOX\u2010induced hyperlipidemia via modulation of lipid metabolism.<\/jats:p>","DOI":"10.1002\/jbt.23329","type":"journal-article","created":{"date-parts":[[2023,2,21]],"date-time":"2023-02-21T05:52:46Z","timestamp":1676958766000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Therapeutic effects of atorvastatin on doxorubicin\u2010induced hepatotoxicity in rats via antioxidative damage, anti\u2010inflammatory, and anti\u2010lipotoxicity"],"prefix":"10.1002","volume":"37","author":[{"given":"Yan\u2010Zhao","family":"Wu","sequence":"first","affiliation":[{"name":"Department of Otorhinolarynology\u2010Head and Neck Sergery The Fourth Hospital of Hebei Medical University Shijiazhuang China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ke\u2010Xin","family":"Wang","sequence":"additional","affiliation":[{"name":"The Key Laboratory of Pharmacology and Toxicology for New 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