{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T02:43:36Z","timestamp":1792118616965,"version":"4.4.0"},"reference-count":62,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2023,4,3]],"date-time":"2023-04-03T00:00:00Z","timestamp":1680480000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Biochem &amp;amp; Molecular Tox"],"published-print":{"date-parts":[[2023,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Oxidative stress is a pathological condition characterized by an overload of oxidant products, named free radicals, which are not well counteracted by antioxidant systems. Free radicals induce oxidative damage to many body organs and systems. In neonatal red blood cells, free\u2010radical mediated\u2010oxidative stress leads to eryptosis, a suicidal death process of erythrocytes consequent to alteration of cell integrity. Neonatal red blood cells are targets and at the same time generators of free radicals through the Fenton and Haber\u2010Weiss reactions. Enhanced eryptosis in case of oxidative stress damage may cause anemia if the increased loss of erythrocytes is not enough compensated by enhanced new erythrocytes synthesis. The oxidative disruption of the red cells may cause unconjugated idiopathic hyperbilirubinemia in neonates. High levels of bilirubin are recognized to be dangerous for the central nervous system in newborns, however, many studies have highlighted the antioxidant function of bilirubin. Recently, it has been suggested that physiologic concentration of bilirubin correlates with higher antioxidant status while high pathological bilirubin levels are associated with pro\u2010oxidants effects. The aim of this educational review is to provide an updated understanding of the molecular mechanisms underlying erythrocyte oxidant injury and its reversal in neonatal idiopathic hyperbilirubinemia.<\/jats:p>","DOI":"10.1002\/jbt.23349","type":"journal-article","created":{"date-parts":[[2023,4,3]],"date-time":"2023-04-03T08:53:36Z","timestamp":1680512016000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Molecular mechanisms of oxidative stress\u2010related neonatal jaundice"],"prefix":"10.1002","volume":"37","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5478-5657","authenticated-orcid":false,"given":"Serafina","family":"Perrone","sequence":"first","affiliation":[{"name":"Department of Medicine and Surgery, Neonatology Unit, 'Azienda Ospedaliero Universitaria di Parma University of Parma Parma Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0357-921X","authenticated-orcid":false,"given":"Chiara","family":"Lembo","sequence":"additional","affiliation":[{"name":"Department of Molecular and Developmental Medicine University of Siena Siena Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maurizio","family":"Giordano","sequence":"additional","affiliation":[{"name":"Department of Clinical Medicine and Surgery Federico II University Naples Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chiara","family":"Petrolini","sequence":"additional","affiliation":[{"name":"Department of Medicine and Surgery, Neonatology Unit, 'Azienda Ospedaliero Universitaria di Parma University of Parma Parma Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura","family":"Cannav\u00f2","sequence":"additional","affiliation":[{"name":"Department of Human Pathology in Adult and Developmental Age \u201cGaetano Barresi\u201d University of Messina Messina Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eloisa","family":"Gitto","sequence":"additional","affiliation":[{"name":"Department of Human Pathology in Adult and Developmental Age \u201cGaetano Barresi\u201d University of Messina Messina Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,4,3]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1080\/713803728"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1155\/2014\/761264"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.13075\/mp.5893.00137"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.2174\/1389557518666181015151350"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.siny.2010.04.003"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.freeradbiomed.2019.03.034"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0036-1593811"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.3390\/medicina55070328"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.placenta.2016.08.084"},{"key":"e_1_2_5_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.siny.2020.101087"},{"key":"e_1_2_5_12_1","doi-asserted-by":"publisher","DOI":"10.1042\/bj2190001"},{"key":"e_1_2_5_13_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awg116"},{"key":"e_1_2_5_14_1","first-page":"188","volume":"13","author":"Bracci R.","year":"2017","journal-title":"Curr Pediatr Rev"},{"key":"e_1_2_5_15_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00424-010-0829-x"},{"key":"e_1_2_5_16_1","doi-asserted-by":"publisher","DOI":"10.1159\/000329956"},{"key":"e_1_2_5_17_1","doi-asserted-by":"publisher","DOI":"10.1159\/000337598"},{"key":"e_1_2_5_18_1","doi-asserted-by":"publisher","DOI":"10.1096\/fj.08-121772"},{"key":"e_1_2_5_19_1","doi-asserted-by":"publisher","DOI":"10.1155\/2015\/513518"},{"key":"e_1_2_5_20_1","doi-asserted-by":"publisher","DOI":"10.1097\/00001703-200104000-00009"},{"key":"e_1_2_5_21_1","doi-asserted-by":"publisher","DOI":"10.1159\/000047088"},{"key":"e_1_2_5_22_1","doi-asserted-by":"publisher","DOI":"10.1203\/00006450-200207000-00010"},{"key":"e_1_2_5_23_1","doi-asserted-by":"publisher","DOI":"10.1159\/000075814"},{"key":"e_1_2_5_24_1","doi-asserted-by":"publisher","DOI":"10.1159\/000240642"},{"key":"e_1_2_5_25_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.1984.tb02947.x"},{"key":"e_1_2_5_26_1","doi-asserted-by":"publisher","DOI":"10.1159\/000208458"},{"key":"e_1_2_5_27_1","doi-asserted-by":"publisher","DOI":"10.1089\/ars.2013.5747"},{"key":"e_1_2_5_28_1","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.2001.013040"},{"key":"e_1_2_5_29_1","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.1998.78.1.247"},{"key":"e_1_2_5_30_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00421-010-1738-6"},{"key":"e_1_2_5_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1388-1981(00)00084-6"},{"key":"e_1_2_5_32_1","doi-asserted-by":"publisher","DOI":"10.1155\/2016\/6051093"},{"key":"e_1_2_5_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0891-5849(02)00759-1"},{"key":"e_1_2_5_34_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1651-2227.2002.tb02918.x"},{"key":"e_1_2_5_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.earlhumdev.2010.03.008"},{"key":"e_1_2_5_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(18)49946-2"},{"key":"e_1_2_5_37_1","doi-asserted-by":"publisher","DOI":"10.3109\/14767058.2012.715471"},{"key":"e_1_2_5_38_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1651-2227.1998.tb01390.x"},{"key":"e_1_2_5_39_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0891-5849(98)00126-9"},{"key":"e_1_2_5_40_1","doi-asserted-by":"publisher","DOI":"10.1080\/1071576021000032122"},{"key":"e_1_2_5_41_1","doi-asserted-by":"publisher","DOI":"10.1159\/000241722"},{"key":"e_1_2_5_42_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1651-2227.1988.tb10659.x"},{"key":"e_1_2_5_43_1","doi-asserted-by":"publisher","DOI":"10.1159\/000244422"},{"key":"e_1_2_5_44_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1754.2004.00489.x"},{"key":"e_1_2_5_45_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.108.3.763"},{"key":"e_1_2_5_46_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.3029864"},{"key":"e_1_2_5_47_1","doi-asserted-by":"publisher","DOI":"10.1016\/0140-6736(91)90074-Y"},{"key":"e_1_2_5_48_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.84.22.8130"},{"key":"e_1_2_5_49_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0188-4409(02)00356-9"},{"key":"e_1_2_5_50_1","doi-asserted-by":"publisher","DOI":"10.1093\/tropej\/fml060"},{"key":"e_1_2_5_51_1","doi-asserted-by":"publisher","DOI":"10.1016\/0014-5793(94)00666-0"},{"key":"e_1_2_5_52_1","doi-asserted-by":"publisher","DOI":"10.1080\/10715762.2018.1478089"},{"key":"e_1_2_5_53_1","doi-asserted-by":"publisher","DOI":"10.1139\/o91-102"},{"key":"e_1_2_5_54_1","doi-asserted-by":"publisher","DOI":"10.1042\/cs0840407"},{"key":"e_1_2_5_55_1","doi-asserted-by":"publisher","DOI":"10.1203\/01.PDR.0000145281.12853.9E"},{"key":"e_1_2_5_56_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13312-017-1127-x"},{"key":"e_1_2_5_57_1","doi-asserted-by":"publisher","DOI":"10.1111\/ijcp.14709"},{"key":"e_1_2_5_58_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1526-9523(01)00196-9"},{"key":"e_1_2_5_59_1","volume":"10","author":"Palethorpe R. J.","year":"2010","journal-title":"Cochrane Database Syst. Rev"},{"key":"e_1_2_5_60_1","doi-asserted-by":"publisher","DOI":"10.1111\/ped.12583"},{"key":"e_1_2_5_61_1","doi-asserted-by":"publisher","DOI":"10.24953\/turkjped.2020.05.006"},{"key":"e_1_2_5_62_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijgo.13615"},{"key":"e_1_2_5_63_1","doi-asserted-by":"publisher","DOI":"10.1055\/a-1739-3529"}],"container-title":["Journal of Biochemical and Molecular Toxicology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jbt.23349","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,10,1]],"date-time":"2024-10-01T06:12:41Z","timestamp":1727763161000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jbt.23349"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,4,3]]},"references-count":62,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2023,6]]}},"alternative-id":["10.1002\/jbt.23349"],"URL":"https:\/\/doi.org\/10.1002\/jbt.23349","archive":["Portico"],"relation":{},"ISSN":["1095-6670","1099-0461"],"issn-type":[{"value":"1095-6670","type":"print"},{"value":"1099-0461","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,4,3]]},"assertion":[{"value":"2022-03-01","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-03-20","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-04-03","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e23349"}}