{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,20]],"date-time":"2026-06-20T02:44:51Z","timestamp":1781923491147,"version":"3.54.5"},"reference-count":41,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2023,3,31]],"date-time":"2023-03-31T00:00:00Z","timestamp":1680220800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Biochem &amp; Molecular Tox"],"published-print":{"date-parts":[[2023,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The prevalence of nonalcoholic fatty liver disease (NAFLD) is much higher in patients with type II diabetes (T2D). Inflammasomes are multimolecular complexes reported to involve inflammatory conditions. The nuclear factor (erythroid\u2010derived 2)\u2010like factor 2\/antioxidant responsive element (Nrf2\/ARE) pathway is an important\u00a0regulator of antioxidant status in cells. Antidiabetic drug glibenclamide (GLB) is reported as \u00a0NACHT, leucine\u2010rich repeat, and pyrin domain domains\u2010containing protein 3 (NLRP3) inflammasome inhibitor, whereas\u00a0anti\u2010multiple sclerosis drug dimethyl fumarate (DMF) is reported as an Nrf2\/ARE pathway activator. Both GLB and DMF possess anti\u2010inflammatory and antioxidant properties, therefore, the hypothesis was made to look into the alone as well as the combination potential of GLB, DMF, and GLB\u2009+\u2009DMF, against NAFLD in diabetic rats. This study was aimed to investigate (1) the involvement of NLRP3 inflammasome and Nrf2\/ARE signaling in diabetes\u2010associated NAFLD (2) the effect of GLB, DMF, GLB\u2009+\u2009DMF, and metformin (MET) interventions on NLRP3 inflammasome and Nrf2\/ARE signaling in diabetes\u2010associated NAFLD. The rats were injected with streptozotocin (STZ) 35\u2009mg\/kg and fed a high\u2010fat diet (HFD) for 17 consecutive weeks to induce diabetic NAFLD. The oral treatment of GLB 0.5\u2009mg\/kg\/day, DMF 25\u2009mg\/kg\/day, their combination and MET 200\u2009mg\/kg\/day, were provided from the 6th to the 17th week. Treatment with GLB, DMF, GLB\u2009+\u2009DMF, and MET significantly alleviated HFD\u2009+\u2009STZ\u2010induced plasma glucose, triglycerides, cholesterol, %HbA1c, hepatic steatosis, NLRP3, apoptosis\u2010associated speck\u2010like protein containing a caspase activation and recruitment domain, CARD, caspase\u20101, interleukin\u20101\u03b2 (IL\u20101\u03b2), nuclear factor\u2010\u03baB (NF\u2010\u03baB), Nrf2, superoxide dismutase 1, catalase, IGF 1, heme oxygenase 1, receptor for the advanced glycation end product (RAGE), and collagen\u20101 in diabetic rats. Further, a mechanistic molecular study employing other specific NLRP3 inhibitors and Nrf2 activators will significantly contribute to the development of novel therapy for fatty liver diseases.<\/jats:p>","DOI":"10.1002\/jbt.23357","type":"journal-article","created":{"date-parts":[[2023,3,31]],"date-time":"2023-03-31T08:49:54Z","timestamp":1680252594000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["Dimethyl fumarate\u2010mediated Nrf2\/ARE pathway activation and glibenclamide\u2010mediated NLRP3 inflammasome cascade inhibition alleviate type II diabetes\u2010associated fatty liver in rats by mitigating oxidative stress and inflammation"],"prefix":"10.1002","volume":"37","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0535-0379","authenticated-orcid":false,"given":"Durgesh K.","family":"Dwivedi","sequence":"first","affiliation":[{"name":"Facility for Risk Assessment and Intervention Studies, Department of Pharmacology and Toxicology National Institute of Pharmaceutical Education and Research S.A.S. Nagar Punjab India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9437-7252","authenticated-orcid":false,"given":"G. B.","family":"Jena","sequence":"additional","affiliation":[{"name":"Facility for Risk Assessment and Intervention Studies, Department of Pharmacology and Toxicology National Institute of Pharmaceutical Education and Research S.A.S. 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