{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T14:46:43Z","timestamp":1786978003322,"version":"build-2736575974"},"reference-count":38,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2023,5,15]],"date-time":"2023-05-15T00:00:00Z","timestamp":1684108800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100005001","name":"Ahvaz Jundishapur University of Medical Sciences","doi-asserted-by":"publisher","award":["APRC\u20109804"],"award-info":[{"award-number":["APRC\u20109804"]}],"id":[{"id":"10.13039\/501100005001","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Biochem &amp; Molecular Tox"],"published-print":{"date-parts":[[2023,7]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:label\/>\n                    <jats:p>\n                      Increasing air pollution is associated with serious human health problems. P\u2010coumaric acid (PC) is a herbal phenolic compound that exhibits beneficial pharmacological potentials. Here, the protective effect of PC on liver injury induced by air pollution was examined. Thirty\u2010two adult male Wistar rats (200\u2010250 g) were divided randomly into four groups (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u20098). The groups were; Control (rats received DMSO and then exposed to clean air), PC (rats received PC and then exposed to clean air), DMSO\u2009+\u2009Dust (rats received DMSO and then exposed to dust), and PC\u2009+\u2009Dust (the animals received PC and then exposed to dust). The clean air, DMSO, PC, and dust were administrated 3 days a week for 6 consecutive weeks. The rats were anesthetized and their blood samples and liver sections were taken to conduct molecular, biomedical, and histopathological tests. Dust exposure increased the liver enzymes, bilirubin, triglyceride, cholesterol, and the production of liver malondialdehyde, and decreased in liver total anti\u2010oxidant capacity and serum high\u2010density lipoprotein. It also increased the mRNA expression of inflammatory\u2010related cytokines, decreased the mRNA expression of SIRT\u20101, decreased the expression levels of miR\u201020b5p, and MEG3 while increased the expression levels of miR\u201034a, and HOTAIR. Dust exposure also increased the liver content of three cytokines TNF\u2010\u03b1, NF\u2010\u03baB, HMGB\u20101, and ATG\u20107 proteins. PC enhanced liver function against adverse effects of dust through recovering almost all the studied variables. Exposure to dust damaged the liver through induction of oxidative stress, inflammation, and autophagy. PC protected the liver against dust\u2010induced cytotoxicity.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/jbt.23364","type":"journal-article","created":{"date-parts":[[2023,5,15]],"date-time":"2023-05-15T06:35:51Z","timestamp":1684132551000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["The protective effect of p\u2010Coumaric acid on hepatic injury caused by particulate matter in the rat and determining the role of long noncoding RNAs MEG3 and HOTAIR"],"prefix":"10.1002","volume":"37","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8774-4835","authenticated-orcid":false,"given":"Mojtaba","family":"Moradi","sequence":"first","affiliation":[{"name":"Persian Gulf Physiology Research Center, Medical Basic Sciences Research Institute Ahvaz Jundishapur University of Medical Sciences Ahvaz Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4323-1672","authenticated-orcid":false,"given":"Seyyed A.","family":"Mard","sequence":"additional","affiliation":[{"name":"Persian Gulf Physiology Research Center, Medical Basic Sciences Research Institute Ahvaz Jundishapur University of Medical Sciences Ahvaz Iran"},{"name":"Alimentary Tract Research Center, Clinical Sciences Research Institute Ahvaz Jundishapur University of Medical Sciences Ahvaz Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yaghoob","family":"Farbood","sequence":"additional","affiliation":[{"name":"Persian Gulf Physiology Research Center, Medical Basic Sciences Research Institute Ahvaz Jundishapur University of Medical Sciences Ahvaz Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mahin","family":"Dianat","sequence":"additional","affiliation":[{"name":"Persian Gulf Physiology Research Center, Medical Basic Sciences Research Institute Ahvaz Jundishapur University of Medical Sciences Ahvaz Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gholamreza","family":"Goudarzi","sequence":"additional","affiliation":[{"name":"Air Pollution and Respiratory Diseases Research Center, Ahvaz Jundishapour University of Medical Sciences, Ahvaz, Iran. Environmental Technologies Research Center Ahvaz Jundishapur University of Medical Sciences Ahvaz Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Layasadat","family":"Khorsandi","sequence":"additional","affiliation":[{"name":"Department of Anatomical Sciences, School of Medicine, Cellular and Molecular Research Center, Medical Basic Sciences Research Institute Ahvaz Jundishapur University of Medical Sciences Ahvaz Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seyed S.","family":"Seyedian","sequence":"additional","affiliation":[{"name":"Alimentary Tract Research Center, Clinical Sciences Research Institute Ahvaz Jundishapur University of Medical Sciences Ahvaz Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,5,15]]},"reference":[{"issue":"1","key":"e_1_2_11_2_1","first-page":"8","volume":"8","author":"Du Y.","year":"2016","journal-title":"J. Thorac. 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