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Chronic inhibition of Na<jats:sup>+<\/jats:sup>\/H<jats:sup>+<\/jats:sup> exchanger (NHE1) reduces heart failure and reduces the production of reactive oxygen species (ROS); vitamin B6 (VitB<jats:sub>6<\/jats:sub>) has been demonstrated to have a crucial role in antioxidant mechanism. So, this study was designed to explore the effect of VitB<jats:sub>6<\/jats:sub> supplement on the DOX\u2010induced cardiotoxicity and to imply whether NHE1 is involved. Ultrasonic cardiogram analysis revealed that VitB<jats:sub>6<\/jats:sub> supplement could alleviate DOX\u2010induced cardiotoxicity; hematoxylin and eosin (HE) and Masson's staining further confirmed this effect. Furthermore, VitB<jats:sub>6<\/jats:sub> supplement exhibited significant antioxidative stress and antiapoptosis effect, which was evidenced by decreased serum malondialdehyde (MDA) content and increased serum superoxide dismutase (SOD) content, and decreased Bcl\u20102\u2010associated X protein\/B\u2010cell lymphoma\u20102 ratio, respectively. Collectively, VitB<jats:sub>6<\/jats:sub> supplement may exert antioxidative and antiapoptosis effects to improve cardiac function by decreasing NHE1 expression and improve DOX\u2010induced cardiotoxicity.<\/jats:p>","DOI":"10.1002\/jbt.23403","type":"journal-article","created":{"date-parts":[[2023,9,13]],"date-time":"2023-09-13T07:59:17Z","timestamp":1694591957000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Protective effect of vitamin B<sub>6<\/sub> against doxorubicin\u2010induced cardiotoxicity by modulating NHE1 expression"],"prefix":"10.1002","volume":"37","author":[{"given":"Rui\u2010li","family":"Sun","sequence":"first","affiliation":[{"name":"Henan Key Laboratory of Immunology and Targeted Drugs, Xinxiang Key Laboratory of Tumor Microenvironment and Immunotherapy, School of Laboratory Medicine Xinxiang Medical University Xinxiang China"},{"name":"Henan International Joint Laboratory of Cardiovascular 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