{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,20]],"date-time":"2026-08-20T14:22:38Z","timestamp":1787235758294,"version":"build-2736575974"},"reference-count":30,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2023,6,19]],"date-time":"2023-06-19T00:00:00Z","timestamp":1687132800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81700226"],"award-info":[{"award-number":["81700226"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Biochem &amp; Molecular Tox"],"published-print":{"date-parts":[[2023,9]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Cardiac fibrosis is an important pathological change after myocardial infarction (MI). High concentration of tumor necrosis factor\u2010\u03b1 (TNF\u2010\u03b1) contributes to cardiac fibrosis, and TNF\u2010\u03b1 has been demonstrated to be involved in transforming growth factor\u2010\u03b21\u2010induced endothelial\u2010to\u2010mesenchymal transition (EndMT). However, the role and molecular mechanisms of TNF\u2010\u03b1 during cardiac fibrosis remain largely unexplored. In this study, we demonstrated that TNF\u2010\u03b1 and endothelin\u20101 (ET\u20101) were upregulated in cardiac fibrosis after MI, and genes associated with EndMT were also upregulated. An in vitro model of EndMT demonstrated that TNF\u2010\u03b1 promoted EndMT by upregulation of vimentin and \u03b1\u2010smooth muscle actin, and which strongly increased ET\u20101 expression. ET\u20101 promoted TNF\u2010\u03b1\u2010induced expression of gene program through phosphorylation levels of SMAD family member 2, while subsequent inhibition of ET\u20101 almost abolished the effect of TNF\u2010\u03b1 during the process of EndMT. In summary, these findings demonstrated that ET\u20101 is involved in the EndMT induced by TNF\u2010\u03b1 during cardiac fibrosis.<\/jats:p>","DOI":"10.1002\/jbt.23411","type":"journal-article","created":{"date-parts":[[2023,6,19]],"date-time":"2023-06-19T04:28:17Z","timestamp":1687148897000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Tumor necrosis factor\u2010\u03b1 stimulation endothelial\u2010to\u2010mesenchymal transition during cardiac fibrosis via endothelin\u20101 signaling"],"prefix":"10.1002","volume":"37","author":[{"given":"Huan","family":"Hu","sequence":"first","affiliation":[{"name":"Department of Pediatric Cardiology Xinhua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jihong","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Pediatric Cardiology Xinhua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shasha","family":"Zhang","sequence":"additional","affiliation":[{"name":"Key Laboratory of Systems Biomedicine, Shanghai Center for Systems Biomedicine Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bing","family":"Zhang","sequence":"additional","affiliation":[{"name":"Key Laboratory of Systems Biomedicine, Shanghai Center for Systems Biomedicine Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7955-5452","authenticated-orcid":false,"given":"Wenjuan","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Pediatric Cardiology Xinhua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kun","family":"Sun","sequence":"additional","affiliation":[{"name":"Department of Pediatric Cardiology Xinhua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,6,19]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIR.0000000000000485"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.115.306565"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrcardio.2017.57"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00441-016-2431-9"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrcardio.2009.199"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajpath.2011.06.001"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.3390\/cells11111834"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1038\/nm1613"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0163-7258(02)00176-6"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pharmthera.2010.05.002"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cdtm.2015.02.002"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.freeradbiomed.2015.02.002"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1161\/hc3401.093154"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10439-013-0894-3"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.110.938217"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI94753"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.3899\/jrheum.150088"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.109.209809"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI40295"},{"issue":"24","key":"e_1_2_8_21_1","volume":"23","author":"Tang J.","year":"2019","journal-title":"Eur. 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