{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,17]],"date-time":"2026-10-17T21:12:43Z","timestamp":1792271563128,"version":"4.4.0"},"reference-count":46,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2023,6,24]],"date-time":"2023-06-24T00:00:00Z","timestamp":1687564800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100012021","name":"Iran University of Medical Sciences","doi-asserted-by":"publisher","award":["19273"],"award-info":[{"award-number":["19273"]}],"id":[{"id":"10.13039\/100012021","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Biochem &amp;amp; Molecular Tox"],"published-print":{"date-parts":[[2023,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Drug\u2010induced liver injury is one of the main challenges that leads to the withdrawal of several drugs in the clinical setting. Cyclosporine is one of the drugs that its long\u2010term administration exerts devastating effects on the hepatocytes. In the present study, we aimed to evaluate the effect of ferulic acid, a natural compound found in plants, on cyclosporine\u2010mediated hepatotoxicity. Forty\u2010eight male Wistar rats were treated with cyclosporine and\/or ferulic acid to evaluate the function as well as the morphology of liver cells. We found that ferulic acid dose\u2010dependently recovered the functional as well as histopathological parameters of liver cells, as revealed by the improvement of hepatocellular vacuolation, portal fibroplasia, and necrosis. Moreover, this phenolic compound was able to restore the balance of the redox system in cyclosporine\u2010treated rats by activating the nuclear factor (NF) erythroid 2\u2010related factor 2 (Nrf2)\/hemeoxygenase\u20101 (HO\u20101) signaling axis. Of note, the protective effects of ferulic acid against cyclosporine\u2010mediated liver toxicity were not restricted only to induction of the potential antioxidant property, as in the presence of this agent, the expression of pro\u2010inflammatory cytokines such as NF\u2010\u03baB, tumor necrosis factor (TNF)\u2010\u03b1, and interleukin\u20101\u03b2 was also diminished. Ferulic acid also shifted the equilibrium between the expression levels of proapoptotic to antiapoptotic proteins and thereby prevented the development of cyclosporine\u2010induced liver injury. Overall, these findings highlighted that ferulic acid can reduce cyclosporine\u2010induced liver injury due to its antioxidant properties.<\/jats:p>","DOI":"10.1002\/jbt.23427","type":"journal-article","created":{"date-parts":[[2023,6,25]],"date-time":"2023-06-25T01:44:43Z","timestamp":1687657483000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["Ferulic acid exerts a protective effect against cyclosporine\u2010induced liver injury in rats via activation of the Nrf2\/HO\u20101 signaling, suppression of oxidative stress, inflammatory response, and halting the apoptotic cell death"],"prefix":"10.1002","volume":"37","author":[{"given":"Ali","family":"Nouri","sequence":"first","affiliation":[{"name":"Clinical Biochemistry Research Center, Basic Health Sciences Institute Shahrekord University of Medical Sciences Shahrekord Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Keihan","family":"Ghatreh\u2010Samani","sequence":"additional","affiliation":[{"name":"Clinical Biochemistry Research Center, Basic Health Sciences Institute Shahrekord University of Medical Sciences Shahrekord Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hossein","family":"Amini\u2010Khoei","sequence":"additional","affiliation":[{"name":"Medical Plant Research Center, Basic Health Sciences Institute Shahrekord University of Medical Sciences Shahrekord Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0622-4174","authenticated-orcid":false,"given":"Mohammad","family":"Najafi","sequence":"additional","affiliation":[{"name":"Department of Biochemistry, School of Medicine Iran University of Medical Sciences Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Esfandiar","family":"Heidarian","sequence":"additional","affiliation":[{"name":"Clinical Biochemistry Research Center, Basic Health Sciences Institute Shahrekord University of Medical Sciences Shahrekord Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,6,24]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra021844"},{"key":"e_1_2_8_3_1","first-page":"233","volume":"2","author":"Pandit A.","year":"2012","journal-title":"J. Appl. Pharm. Sci."},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.2174\/0929867327666201006153202"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1155\/2016\/5823271"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1080\/13813455.2019.1659826"},{"key":"e_1_2_8_7_1","doi-asserted-by":"crossref","first-page":"27","DOI":"10.31351\/vol21iss1pp27-33","volume":"21","author":"Attyah A. M.","year":"2012","journal-title":"Iraqi J. Pharm. Sci"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.toxlet.2004.03.002"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1159\/000226296"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.etp.2008.04.007"},{"key":"e_1_2_8_11_1","first-page":"392","volume":"18","author":"Alozhy M.","year":"2019","journal-title":"Basrah J. Vet. Res."},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/jsfa.1873"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.lfs.2021.119921"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.intimp.2019.105980"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu10060713"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11356-019-07532-6"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2210-8-4"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.2147\/DDDT.S237107"},{"key":"e_1_2_8_19_1","volume-title":"Theory and Practice of Histological Techniques","author":"Banchroft J.","year":"1996"},{"key":"e_1_2_8_20_1","first-page":"2717","volume":"5","author":"Heidarian E.","year":"2011","journal-title":"J. Med. Plants Res."},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1080\/10715760802513733"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1570-0232(02)00273-8"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0076-6879(94)33041-7"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/0003-2697(71)90370-8"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.3109\/19390211.2013.859217"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1007\/s43450-021-00220-y"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/0003-9861(59)90090-6"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.intimp.2019.105984"},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.1186\/s41936-019-0108-0"},{"key":"e_1_2_8_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.lfs.2020.118780"},{"key":"e_1_2_8_31_1","first-page":"1","volume":"10","author":"Althaiban M. A.","year":"2019","journal-title":"J. Biochem. Technol."},{"key":"e_1_2_8_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.joms.2018.02.030"},{"key":"e_1_2_8_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.proghi.2004.04.001"},{"key":"e_1_2_8_34_1","doi-asserted-by":"publisher","DOI":"10.3390\/antiox8090353"},{"key":"e_1_2_8_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cccn.2004.03.035"},{"key":"e_1_2_8_36_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-079X.2007.00441.x"},{"key":"e_1_2_8_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cbi.2014.11.007"},{"key":"e_1_2_8_38_1","doi-asserted-by":"publisher","DOI":"10.1002\/jnr.20879"},{"key":"e_1_2_8_39_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejphar.2016.04.047"},{"key":"e_1_2_8_40_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2018.10.019"},{"key":"e_1_2_8_41_1","doi-asserted-by":"publisher","DOI":"10.1089\/ars.2017.7358"},{"key":"e_1_2_8_42_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2018.01428"},{"key":"e_1_2_8_43_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12035-018-1280-9"},{"key":"e_1_2_8_44_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0960-9822(99)80059-1"},{"key":"e_1_2_8_45_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molmed.2017.11.002"},{"key":"e_1_2_8_46_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuint.2005.05.010"},{"key":"e_1_2_8_47_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eplepsyres.2019.106183"}],"container-title":["Journal of Biochemical and Molecular Toxicology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jbt.23427","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,12,27]],"date-time":"2024-12-27T17:27:58Z","timestamp":1735320478000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jbt.23427"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,6,24]]},"references-count":46,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2023,10]]}},"alternative-id":["10.1002\/jbt.23427"],"URL":"https:\/\/doi.org\/10.1002\/jbt.23427","archive":["Portico"],"relation":{},"ISSN":["1095-6670","1099-0461"],"issn-type":[{"value":"1095-6670","type":"print"},{"value":"1099-0461","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,6,24]]},"assertion":[{"value":"2022-01-18","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-06-12","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-06-24","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e23427"}}