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THP\u20101 cells were induced to M2 phenotype macrophages and co\u2010cultured with AGS cells. The effects of DIO were determined by flow cytometry, qRT\u2010PCR, CCK\u20108, Transwell, and western blot. To explore the mechanisms, THP\u20101 cells were transfected with adenoviral vectors containing tumor necrosis factor receptor\u2010associated factor 2 (TRAF2) or si\u2010TRAF2. DIO (0, 5, 10, and 20\u2009\u03bcM) restrained the M2 phenotype macrophage polarization. In addition, DIO (20\u2009\u03bcM) reversed the increased viability and invasion of AGS cells induced by the co\u2010culture of M2 macrophages. Mechanistically, TRAF2 knockdown inhibited the effect of M2 phenotype macrophages on AGS cells'\u00a0growth and invasion. Furthermore, DIO (20\u2009\u03bcM) was found to decrease TRAF2\/NF\u2010\u03baB activity in GC cells. However, TRAF2 overexpressed reversed the inhibitory effect of DIO on the co\u2010culture system. The in vivo study confirmed that DIO treatment (50\u2009mg\/kg) could repress the growth of GC. DIO treatment markedly reduced the expressions of Ki\u201067 and N\u2010cadherin, and decreased the protein levels of TRAF2 and p\u2010NF\u2010\u03baB\/NF\u2010\u03baB. In conclusion, DIO inhibited the growth and invasion of GC cells by interfering with M2 phenotype macrophage polarization through repression of the TRAF2\/NF\u2010\u03baB signaling pathway.<\/jats:p>","DOI":"10.1002\/jbt.23431","type":"journal-article","created":{"date-parts":[[2023,6,28]],"date-time":"2023-06-28T08:59:24Z","timestamp":1687942764000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["RETRACTED: Diosmetin inhibits the growth and invasion of gastric cancer by interfering with M2 phenotype macrophage polarization"],"prefix":"10.1002","volume":"37","author":[{"given":"Faqiang","family":"Zhang","sequence":"first","affiliation":[{"name":"Department of General Surgery Zigong Fourth People's Hospital Zigong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7417-3321","authenticated-orcid":false,"given":"Huan","family":"Luo","sequence":"additional","affiliation":[{"name":"Department of General Surgery Yubei District Hospital of Traditional Chinese Medicine Chongqing China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,6,28]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/jso.26844"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1159\/000506509"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2020.571516"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.3389\/fgene.2020.00663"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/cas.14521"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.2174\/1568009622666220705095403"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbcan.2020.188434"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12885-022-09872-y"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40659-021-00363-1"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/ptr.6596"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.lfs.2018.11.029"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.3390\/biomedicines10030531"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1039\/D1FO02111G"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12032-021-01501-1"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/bph.14652"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2022.983821"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.intimp.2014.08.002"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12885-015-1546-9"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.3390\/molecules24142522"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.21037\/atm-21-4617"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.imbio.2014.05.005"},{"issue":"4","key":"e_1_2_10_23_1","first-page":"1215","volume":"60","author":"Dochi\u0163 C. 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