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Our study focuses on the evaluation of potential metformin protective effects on brain and cerebellum damage in streptozotocin (STZ)\u2010induced diabetic and Dunning prostate cancer models. In this investigation, six groups of male Copenhagen rats were created: control, diabetic (D), cancer (C), diabetic\u2009+\u2009cancer (DC), cancer\u2009+\u2009metformin, and diabetic\u2009+\u2009cancer\u2009+\u2009metformin. The brain and cerebellum tissues of the rats were taken after sacrifice. Oxidative stress markers including reduced glutathione level, lipid peroxidation, glutathione reductase, glutathione peroxidase, glutathione\u2010<jats:italic>S<\/jats:italic>\u2010transferase, catalase, superoxide dismutase activities, reactive oxygen species, total oxidant and total antioxidant status, lactate dehydrogenase, xanthine oxidase, acetylcholinesterase activities, protein carbonyl contents, nitric oxide and OH\u2010proline levels, sodium potassium ATPase, carbonic anhydrase, and glucose\u20106\u2010phosphate dehydrogenase activities; glycoprotein levels including hexose, hexosamine, fucose, and sialic acid levels; and histone deacetylase activity as a cancer marker were determined. Oxidative stress markers were impaired and glycoprotein levels and histone deacetylase activity were increased in the D, C, and DC groups. Metformin therapy reversed these effects. Metformin was found to protect the brain and cerebellum of STZ\u2010induced diabetic rats with Dunning prostate cancer from harm caused by MAT\u2010Lylu metastatic cells.<\/jats:p>","DOI":"10.1002\/jbt.23440","type":"journal-article","created":{"date-parts":[[2023,6,25]],"date-time":"2023-06-25T01:45:21Z","timestamp":1687657521000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Oxidative brain and cerebellum injury in diabetes and prostate cancer model: Protective effect of metformin"],"prefix":"10.1002","volume":"37","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0395-1058","authenticated-orcid":false,"given":"Eda","family":"Dagsuyu","sequence":"first","affiliation":[{"name":"Department of Chemistry, Faculty of Engineering Istanbul University\u2010Cerrahpa\u015fa Istanbul Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3408-7867","authenticated-orcid":false,"given":"P\u0131nar","family":"Koroglu","sequence":"additional","affiliation":[{"name":"Department of Histology and Embryology, Faculty of Medicine Halic University Istanbul Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2838-0941","authenticated-orcid":false,"given":"Ilknur B.","family":"Gul","sequence":"additional","affiliation":[{"name":"Department of Biology, Faculty of Science Istanbul University Istanbul Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6591-7317","authenticated-orcid":false,"given":"Omur K.","family":"Bulan","sequence":"additional","affiliation":[{"name":"Department of Biology, Faculty of Science Istanbul University Istanbul Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4185-4363","authenticated-orcid":false,"given":"Refiye","family":"Yanardag","sequence":"additional","affiliation":[{"name":"Department of Chemistry, Faculty of Engineering Istanbul University\u2010Cerrahpa\u015fa Istanbul Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,6,24]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.7257\/1053-816X.2016.36.1.27"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1353\/pbm.2019.0046"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1463-1326.2004.00448.x"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.38415.708634.F7"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1093\/neuonc\/nov100"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.5966\/sctm.2012-0058"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1080\/15384101.2016.1186316"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.4161\/cc.23050"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11934-017-0693-8"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1042\/bj3480607"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(08)70235-3"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2008.17.9945"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2011.36.2723"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eururo.2014.04.027"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1177\/0960327120947452"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1080\/15376516.2021.1919810"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1002\/cbf.3674"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/bcpt.12484"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0107220"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1155\/2013\/231378"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(19)52451-6"},{"key":"e_1_2_8_23_1","volume-title":"Red Blood Cell Metabolism: A Manual of Biochemical Methods","author":"Beutler E.","year":"1975"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/0009-8981(86)90247-0"},{"key":"e_1_2_8_25_1","unstructured":"E.Beutler inRed Cell Metabolism. 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