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According to immunological characteristics and overall survival, cohorts of glioma patients from public databases were separated into two TME\u2010relevant clusters in this analysis. Based on differentially expressed genes between TME clusters and correlative regression analysis, a 21\u2010gene molecular classifier of TME\u2010related prognostic signature (TPS) was constructed. Afterward, the prognostic efficacy and effectiveness of TPS were assessed in the training and validation groups. The outcome demonstrated that TPS might be utilized alone or in conjunction with other clinical criteria to act as a superior prognostic predictor for glioma. Also, high\u2010risk glioma patients classified by TPS were considered to associate with enhanced immune infiltration, greater tumor mutation, and worse general prognosis. 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