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After nicotinamide (120\u2009mg\/kg) treatment, STZ (60\u2009mg\/kg) was administrated intravenously to induce T2D. Rats with fasting blood glucose (FBG)\u2009&gt;\u2009200\u2009mg\/dL are chosen for the study 7 days after T2D induction. The eupafolin treatment was continued for another 15 days. FBG and an oral glucose tolerance test (OGTT) were measured on the 21st day after T2D induction. The blood lipid, serum insulin, and homeostatic model assessment (HOMA\u2010IR) were determined. In liver homogenate, oxidative stress indicators were measured. In addition, the effect of eupafolin on the expression of the proteins InsR, insulin receptor substrate (IRS)\u20102, GLUT4, PPAR\u03b3, and phosphatidylinositol 3\u2010kinase (PI3K)\/Akt was investigated using a western blot. As measured by OGTT and HOMA\u2010IR, eupafolin treatment reduced FBG and insulin resistance (IR). Furthermore, when compared to diabetic rats, liver antioxidant enzymes were dramatically normalized. The level of glycogen in the liver of diabetic rats was increased by eupafolin treatment. In T2D rats, eupafolin dramatically increased the InsR, IRS\u20102, GLUT4, and PPAR\u03b3. Further, the eupafolin treatment activated the PI3K\/Akt signaling in T2D rats. These findings imply that the antidiabetic mechanism of eupafolin may be related to the activation of the PPAR\u03b3 and the PI3K\/Akt signaling pathway in T2D rats. As a result, the flavonoid eupafolin could be an antidiabetic medication for T2D after a comprehensive clinical investigation.<\/jats:p>","DOI":"10.1002\/jbt.23463","type":"journal-article","created":{"date-parts":[[2023,8,11]],"date-time":"2023-08-11T16:24:56Z","timestamp":1691771096000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Antidiabetic activity of eupafolin through peroxisome proliferator\u2010activated receptor\u2010gamma and PI3K\/Akt signaling in Type 2 diabetic rats"],"prefix":"10.1002","volume":"37","author":[{"given":"Su","family":"Wu","sequence":"first","affiliation":[{"name":"Department of General Medicine Jiangxi Provincial People's Hospital, The First Affiliated Hospital of Nanchang Medical College Nanchang City Jiangxi Province China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wenwei","family":"Ai","sequence":"additional","affiliation":[{"name":"Department of General Medicine Jiangxi Provincial People's Hospital, The First Affiliated Hospital of Nanchang Medical College Nanchang City Jiangxi Province China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lei","family":"Nie","sequence":"additional","affiliation":[{"name":"Department of Geriatrics Jiangxi Provincial People's Hospital, The First Affiliated Hospital of Nanchang Medical College Nanchang City Jiangxi Province China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0273-166X","authenticated-orcid":false,"given":"Xiao","family":"Lu","sequence":"additional","affiliation":[{"name":"Department of Inpatient Service Center Jiangxi Provincial People's Hospital, The First Affiliated Hospital of Nanchang Medical College Nanchang City Jiangxi Province China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2023,8,11]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(00)80709-6"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1186\/1743-7075-2-5"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12967-015-0412-5"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1186\/1472-6882-14-198"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0031219"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1006\/bbrc.1993.2111"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.271.49.31372"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1038\/nm1001-1133"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/0005-2760(96)00066-5"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.med.53.082901.104018"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.2337\/dc10-2235"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2014.08.005"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2011.10.002"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2011.05.040"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/mnfr.200900305"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/mc.22139"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0891-5849(02)00751-7"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1093\/ecam\/neh099"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1093\/clinchem\/18.6.499"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00280883"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(19)52451-6"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1080\/09553000600876686"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/0304-4165(90)90100-B"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1042\/bj0570410"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.phrs.2004.06.002"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.3109\/13880200903527736"},{"issue":"8","key":"e_1_2_8_28_1","first-page":"800","volume":"48","author":"Veerapur V. 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