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This study investigates the protective role of farnesol (FAR) (C<jats:sub>15<\/jats:sub>H<jats:sub>26<\/jats:sub>O), a natural sesquiterpene alcohol in essential oils, against APAP\u2010induced acute liver necrosis in mice. Mice were injected with a single dose of APAP (300\u2009mg\/kg) via an intraperitoneal route. Different groups of mice were concurrently treated with a single dose of FAR 25\u2009mg\/kg, FAR 50\u2009mg\/kg, and <jats:italic>N<\/jats:italic>\u2010acetylcysteine. APAP administration caused a significant increase in transaminase activities and malondialdehyde (MDA) levels in the serum and liver tissue, respectively, with a concomitant decrease in\u00a0intracellular antioxidants, including reduced glutathione (GSH) in the liver tissue. APAP intoxication upregulated proinflammatory cytokines such as tumor necrosis factor\u2010\u03b1, interleukin\u20101\u03b2\u00a0(IL\u20101\u03b2), IL\u20106, nuclear factor\u2010\u03baB (NF\u2010\u03baB), and I\u03baB kinase \u03b2 in the liver tissue. FAR and <jats:italic>N<\/jats:italic>\u2010acetylcysteine (NAC) administrations concurrently with APAP prevented\u00a0serum transaminase increase in serum and MDA levels in the liver tissue. A high dose of FAR and NAC treatments significantly inhibited GSH and other antioxidant depletion. FAR and NAC treatments also downregulated the expression of proinflammatory markers. FAR treatments protects against APAP\u2010induced acute liver injury and offers antioxidant and anti\u2010inflammatory effects by inhibiting the NF\u2010\u03baB pathway involved in the transcription of genes responsible for inflammatory cytokine synthesis.<\/jats:p>","DOI":"10.1002\/jbt.23478","type":"journal-article","created":{"date-parts":[[2023,7,17]],"date-time":"2023-07-17T09:27:48Z","timestamp":1689586068000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Concurrent administration of farnesol protects acetaminophen\u2010induced acute hepatic necrosis in mice"],"prefix":"10.1002","volume":"37","author":[{"given":"Ramalingam","family":"Gayatri Devi","sequence":"first","affiliation":[{"name":"Department of Physiology, Saveetha Dental College Saveetha Institute of Medical and Technical Sciences Chennai Tamil Nadu India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5068-2383","authenticated-orcid":false,"given":"Devaraj","family":"Ezhilarasan","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, Saveetha Dental College Saveetha Institute of Medical and Technical Sciences Chennai Tamil Nadu India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,7,17]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cnc.2022.04.007"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejim.2021.10.035"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1080\/01480545.2019.1679829"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/liv.12958"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0404.2008.01009.x"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.5604\/01.3001.0010.8633"},{"key":"e_1_2_8_8_1","volume":"26","author":"Zhao H.","year":"2020","journal-title":"Med. 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